ChemicalBook >> CAS DataBase List >>N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide structure

CAS No.: 916141-36-1

Chemical Name:: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

Synonyms: CS-916;TCS-102;TCS 1102;TCS1102; TCS-1102;TCS 1102 , CID11960895;N-2-Biphenylyl-1-{[(1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl }-L-prolinamide;(2S)-1-[2-(1-METHYLBENZIMIDAZOL-2-YL)SULFANYLACETYL]-N-(2-PHENYLPHENYL)PYRROLIDINE-2-CARBOXAMIDE;N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide

CBNumber:: CB52518973

Molecular Formula:: C27H26N4O2S

Molecular Weight:: 470.59

MDL Number:: MFCD18086894

MOL File:: 916141-36-1.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Properties

storage temp.	Sealed in dry,2-8°C
solubility	DMF: 25 mg/ml; DMF:PBS (pH 7) (1:10): 0.09 mg/ml; DMSO: 14 mg/ml; Ethanol: 10 mg/ml
form	Powder

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H317
Precautionary statements	P280-P305+P351+P338

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18495	TCS 1102 ≥98%	916141-36-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	18495	TCS 1102 ≥98%	916141-36-1	5mg	$100	2024-03-01	Buy
Cayman Chemical	18495	TCS1102 ≥98%	916141-36-1	25mg	$305	2024-03-01	Buy
Cayman Chemical	18495	TCS 1102 ≥98%	916141-36-1	10mg	$169	2024-03-01	Buy
Tocris	3818	TCS1102 ≥98%(HPLC)	916141-36-1	10	$176	2021-12-16	Buy

Product number	Packaging	Price	Buy
18495	1mg	$32	Buy
18495	5mg	$100	Buy
18495	25mg	$305	Buy
18495	10mg	$169	Buy
3818	10	$176	Buy

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Chemical Properties,Uses,Production

Description

Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (K_is = 0.2 and 3 nM, respectively). It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally. Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse. Systemic injection of TCS 1102 (10 mg/kg i.p.) in rats decreases fear and anxiety in response to acute episodes of stress.

Uses

TCS 1102 is a dual antagonist of both OX1R and OX2R. It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally. Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse.

storage

Store at RT

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Suppliers

Global( 69)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei Hirisun Pharmatech Co., Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
3B Pharmachem (Wuhan) International Co.,Ltd.	69

View Lastest Price from N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-06	TCS 1102 916141-36-1	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

TCS 1102
916141-36-1
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Spectrum

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide(916141-36-1)¹HNMR

916141-36-1(N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide)Related Search:

TC-O 9311 TC-2153

(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide TCS-102 (2S)- 2-Pyrrolidinecarboxamide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl] 2-PyrrolidinecarboxaMide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-Methyl-1H-benziMidazol-2-yl)thio]acetyl]-, (2S)- (2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide TCS1102 TCS 1102 N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide TCS 1102 (2S)-1-[2-(1-METHYLBENZIMIDAZOL-2-YL)SULFANYLACETYL]-N-(2-PHENYLPHENYL)PYRROLIDINE-2-CARBOXAMIDE TCS 1102 , CID11960895 CS-916 TCS1102; TCS-1102 N-2-Biphenylyl-1-{[(1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl }-L-prolinamide TCS-1102,pharmacodynamic model,inhibit,TCS1102,orexin,central activity,Orexin Receptor (OX Receptor),post-traumatic stress disorder,TCS 1102,HCRT Receptor,Hypocretin Receptor,Inhibitor,T-maze,hypocretin,fear,anxiety (S)-N-([1,1'-Biphenyl]-2-yl)-1-(2-((1-methyl-1H-benzo[d]imidazol-2-yl)thio)acetyl)pyrrolidine-2-carboxamide N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide (S)-N-([1,1'-Biphenyl]-2-yl)-1-(2-((1-methyl-1H-benzo[d]imidazol-2-yl)thio)acetyl)pyrrolidine-2-carboxamide 916141-36-1 Inhibitors