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CAY10595

CAY10595 Structure
CAY10595 structure
CAS No.
916047-16-0
Chemical Name:
CAY10595
Synonyms
CAY10595;CAY10595,CAY-10595;CAY10595 Exclusive;IXKFWNVFUXXEFY-UHFFFAOYSA-N;Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-
CBNumber:
CB52590436
Molecular Formula:
C20H13Cl2FN2O5
Molecular Weight:
451.23
MDL Number:
MFCD18427989
MOL File:
916047-16-0.mol
Last updated:2023-09-04 15:51:00
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CAY10595 Properties

storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.5 mg/ml; Ethanol: 25 mg/ml
form A crystalline solid

CAY10595 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10012553 CAY10595 ≥97% 916047-16-0 1mg $66 2024-03-01 Buy
Cayman Chemical 10012553 CAY10595 ≥97% 916047-16-0 5mg $291 2024-03-01 Buy
Cayman Chemical 10012553 CAY10595 ≥97% 916047-16-0 10mg $516 2024-03-01 Buy
AK Scientific 1879CW 2-[5-Chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]aceticacid 916047-16-0 10mg $672 2021-12-16 Buy
Product number Packaging Price Buy
10012553 1mg $66 Buy
10012553 5mg $291 Buy
10012553 10mg $516 Buy
1879CW 10mg $672 Buy

CAY10595 Chemical Properties,Uses,Production

Description

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2.1 CAY10595, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM.2 The R enantiomer of CAY10595 is significantly more potent exhibiting Ki values of 5.3 and 5 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.2

References

1. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001).
2. Crosignani, S., Page, P., Missotten, M., et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases J. Med. Chem. 51,2227-2243(2008).

CAY10595 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10595 Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12527 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 18521732826; market@aladdin-e.com China 25015 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Chongqing Chemieliva Pharmaceutical Co., Ltd. 023-67770219 jessica.hu@chemieliva.com China 1423 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Supplier Advantage
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai EFE Biological Technology Co., Ltd. 58
Chongqing Chemieliva Pharmaceutical Co., Ltd. 60
Fan De(Beijing) Biotechnology Co., Ltd. 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

CAY10595 Spectrum

CAY10595(916047-16-0)1HNMR
CAY10595 CAY10595 Exclusive IXKFWNVFUXXEFY-UHFFFAOYSA-N Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo- CAY10595,CAY-10595 916047-16-0