L-161,982
- CAS No.
- 147776-06-5
- Chemical Name:
- L-161,982
- Synonyms
- L-161,982;L-161,982 >=98% (HPLC);colon,cancer,phosphorylation,prostaglandin,Prostaglandin Receptor,L161982,arthritis,inhibit,proliferation,L 161982,L-161982,Inhibitor;N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide;N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]- 2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide;2-Thiophenecarboxamide, N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-
- CBNumber:
- CB31074878
- Molecular Formula:
- C32H29F3N4O4S2
- Molecular Weight:
- 654.72
- MDL Number:
- MFCD09959710
- MOL File:
- 147776-06-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
WGK Germany | 3 |
L-161,982 price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0690 | L-161,982 ≥98% (HPLC) | 147776-06-5 | 5mg | $66.4 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0690 | L-161,982 ≥98% (HPLC) | 147776-06-5 | 25mg | $664 | 2024-03-01 | Buy |
Cayman Chemical | 10011565 | L-161,982 ≥95% | 147776-06-5 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 10011565 | L-161,982 ≥95% | 147776-06-5 | 5mg | $161 | 2024-03-01 | Buy |
Cayman Chemical | 10011565 | L-161,982 ≥95% | 147776-06-5 | 25mg | $704 | 2024-03-01 | Buy |
L-161,982 Chemical Properties,Uses,Production
Description
Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-
Uses
L-161,982 is an EP4 receptor antagonist, which blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
Definition
ChEBI: N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methyl-2-thiophenecarboxamide is a member of biphenyls.
Biological Activity
EP 4 receptor antagonist that is selective over all other members of the prostanoid receptor family (K i values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μ M for human EP 4 , TP, EP 3 , DP, FP, IP, EP 1 and EP 2 receptors respectively). Suppresses PGE 2 -induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.
Biochem/physiol Actions
L-161,982 is a potent EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively.
storage
Desiccate at +4°C
L-161,982 Preparation Products And Raw materials
Raw materials
Preparation Products
L-161,982 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |