URB937
- CAS No.
- 1357160-72-5
- Chemical Name:
- URB937
- Synonyms
- URB937;URB937 ，S3586;URB937, 10 mM in DMSO;3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate;[3-(3-carbamoylphenyl)-4-hydroxyphenyl] N-cyclohexylcarbamate;3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate;Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester;Carbamic acid, N-cyclohexyl-, 3'-(aminocarbonyl)-6-hydroxy[1,1'-biphenyl]-3-yl ester;FAAH,URB 937,Inhibitor,URB937,low,toxicity,inhibit,Fatty acid amide hydrolase,OEA,URB-937
- CBNumber:
- CB52592814
- Molecular Formula:
- C20H22N2O4
- Molecular Weight:
- 354.4
- MDL Number:
- MFCD22987960
- MOL File:
- 1357160-72-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 562.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| pka | 9.08±0.50(Predicted) |
| form | powder (1:1 ratio of product to ethanol) |
| color | white to beige |
| InChI | 1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25) |
| InChIKey | CMEQHOXCIGFZNJ-UHFFFAOYSA-N |
| SMILES | N(C3CCCCC3)C(=O)Oc1cc(c(cc1)O)c2cc(ccc2)C(=O)N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
URB937 price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0448 | URB937 ≥95% (HPLC) | 1357160-72-5 | 5mg | $105 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0448 | URB937 ≥95% (HPLC) | 1357160-72-5 | 25mg | $408 | 2026-04-30 | Buy |
| Cayman Chemical | 10674 | URB937 ≥95% | 1357160-72-5 | 5mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 10674 | URB937 ≥95% | 1357160-72-5 | 10mg | $84 | 2026-04-30 | Buy |
| Cayman Chemical | 10674 | URB937 ≥95% | 1357160-72-5 | 50mg | $344 | 2026-04-30 | Buy |
URB937 Chemical Properties, Uses, Production
Uses
URB 937 is a potent inhibitor of fatty-acid amide hydrolase (FAAH), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. It is actively extruded from the central nervous system (CNS), and therefore increases anandamide levels exclusively in peripheral tissues.
Biological Activity
URB937 is a fatty acid amide hydrolase (FAAH) inhibitor th at is actively excluded from the CNS by the membrane transporter ABCG2. The ED50 for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.
in vivo
URB937 (1 mg/kg, i.p.) administrated in mice increases anandamide levels in peripheral tissues, but not forebrain or hypothalamus[1].
URB937 (1 mg/kg, s.c.) suppresses pain responses elicited by i.p. injections of acetic acid[1].
URB937 in male rats (an oral dose 3 mg/kg, F = 36%) is absorbed at a moderate rate and displays a peak plasma concentration (Cmax) of 159.47 ng/ml, which was achieved one hour after administration. URB937 exhibits T1/2 of 60 min by an oral dose of 3 mg/kg[2].
URB937 produces a high degree of antinociception in female mice and rats in models of visceral and inflammatory pain. Moreover, the compound displayed a restricted access to placental and fetal tissues in pregnant mice and rats[3].
URB937 (1 mg/kg, every 2 days for 30 days) attenuates radiation-induced lung injury and increased endocannabinoid concentration in lung tissue[4].
| Animal Model: | Swiss Webster mice[1]. |
| Dosage: | 1 mg/kg. |
| Administration: | S.C. |
| Result: | Suppressesd pain responses elicited by i.p. injections of acetic acid. |
| Animal Model: | Adult Sprague Dawley male and female rats (250-300 g)[2]. |
| Dosage: | 0.3, 1, 3, 10 mg/kg (Pharmacokinetic Analysis). |
| Administration: | Single oral dose. |
| Result: | Inhibited liver FAAH activity with a median effective dose (ED50) of 0.9 mg/kg. Inhibits FAAH in peripheral tissues and identify a possible biomarker for target engagement. |
URB937 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4865 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400-6387771-6039 18920764717 | sales@heowns.com | China | 24699 | 60 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4184 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684; | sales@rrkchem.com | China | 57330 | 58 |
