8]naphthyridin-6(5H)-one
![8]naphthyridin-6(5H)-one Structure](CAS/20150408/GIF/53439-81-9.gif)
- CAS No.
- 53439-81-9
- Chemical Name:
- 8]naphthyridin-6(5H)-one
- Synonyms
- XU1;XU1,XU-1;benzo[c][1;8]naphthyridin-6(5H)-one;benzo[c][1,8]naphthyridin-6(5h)-one
- CBNumber:
- CB52616640
- Molecular Formula:
- C12H8N2O
- Molecular Weight:
- 196.2
- MDL Number:
- MFCD12828371
- MOL File:
- 53439-81-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
8]naphthyridin-6(5H)-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0370392 | Benzo[c][1,8]naphthyridin-6(5H)-one ≥98% | 53439-81-9 | 1mg | $599 | 2026-06-04 | Buy |
| ChemScene | CS-0370392 | Benzo[c][1,8]naphthyridin-6(5H)-one ≥98% | 53439-81-9 | 5mg | $2097 | 2026-06-04 | Buy |
| Matrix Scientific | 189054 | benzo[c][1,8]naphthyridin-6(5H)-one | 53439-81-9 | 1.00g | $1050 | 2026-05-18 | Buy |
| Matrix Scientific | 189054 | benzo[c][1,8]naphthyridin-6(5H)-one | 53439-81-9 | 5.00g | $3750 | 2026-05-18 | Buy |
| aablocks | AA00E3D6 | Benzo[c][1,8]naphthyridin-6(5H)-one | 53439-81-9 | 1mg | $248 | 2026-05-28 | Buy |
8]naphthyridin-6(5H)-one Chemical Properties, Uses, Production
Description
XU1 is a potent and selective pan Aurora inhibitor; Phosphorylation of histone H3 (pHH3) inhibitor.
Uses
Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM[1][2][3].
IC 50
PARP-1: 0.311 μM (IC50); Aurora A: 5.5 μM (IC50); hA1AR: 4.6 μM (Ki); hA2AAR: 4.8 μM (Ki)
References
[1] van der Horst E, et al., Multi-objective evolutionary design of adenosine receptor ligands. J Chem Inf Model. 2012 Jul 23;52(7):1713-21. DOI:10.1021/ci2005115
[2] Ferraris D, et al., Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. J Med Chem. 2003 Jul 3;46(14):3138-51. DOI:10.1021/jm030109s
[3] Karra S, et al., SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3081-7. DOI:10.1016/j.bmcl.2013.03.008
8]naphthyridin-6(5H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
8]naphthyridin-6(5H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Ningbo Zhenyue Pharmaceutical Technology Co., Ltd | 19817745290 | bd@blocksynth.com | China | 6406 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Hebei Yaocheng Pharmaceutical Technology Co. Ltd | 19903117580 19903117510 | yc-eliu@yaochengph.com | China | 9906 | 58 |
| Hefei Molybdenum Kai Pharmaceutical Technology Co., Ltd | 18001872185; 18001872185 | 690231469@qq.com | China | 20000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
