ChemicalBook >> CAS DataBase List >>2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- structure

CAS No.: 852391-19-6

Chemical Name:: 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

Synonyms: Necrostatin 2;(±)-Necrostatin-2;Necroptotic Inhibitor;Necrostatin 2 R-isomer;MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR;(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione;5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione (5R)-;2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

CBNumber:: CB52626148

Molecular Formula:: C13H12ClN3O2

Molecular Weight:: 277.71

MDL Number:

MOL File:: 852391-19-6.mol

Last updated:2025-12-04 14:24:59

Product description	Number	Pack Size	Price
Necrostatin-2 ≥98%	11657	1mg	$33
Necrostatin-2 ≥98%	11657	5mg	$120
Necrostatin-2 ≥98%	11657	10mg	$223
Necrostatin2	A3652	5mg	$273
(5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione	6577CS	10mg	$345

Request For Quotation

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Properties

Density	1.450±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	crystalline solid
pka	8.48±0.70(Predicted)
color	White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P260-P280-P301+P310

HS Code

2933998090

NFPA 704

	0
3		0

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11657	Necrostatin-2 ≥98%	852391-19-6	1mg	$33	2024-03-01	Buy
Cayman Chemical	11657	Necrostatin-2 ≥98%	852391-19-6	5mg	$120	2024-03-01	Buy
Cayman Chemical	11657	Necrostatin-2 ≥98%	852391-19-6	10mg	$223	2024-03-01	Buy
ApexBio Technology	A3652	Necrostatin2	852391-19-6	5mg	$273	2021-12-16	Buy
AK Scientific	6577CS	(5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione	852391-19-6	10mg	$345	2021-12-16	Buy

Product number	Packaging	Price	Buy
11657	1mg	$33	Buy
11657	5mg	$120	Buy
11657	10mg	$223	Buy
A3652	5mg	$273	Buy
6577CS	10mg	$345	Buy

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Chemical Properties,Uses,Production

Uses

Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor.

Biological Activity

necrostatin 2 (nec-2) is a novel and potent necroptosis inhibitor with ec50 of 50 nm. it is an analog of necrostatin 1 (nec-1).necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.nec-2 is efficacious in an animal model of ischemic stroke. many necroptosis inhibitor derivatives are designed for researchers. there is limited record for nec-2, but some reports are related with other necrostatins. nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase rip1 in vitro.

target

RIPK2

IC 50

RIPK1

References

[1]. teng x, keys h, jeevanandam a, structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. bioorg med chem lett. 2007 dec 15;17(24):6836-40.

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Suppliers

Global( 54)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19961	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53899	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
DebyeTec.com Inc.	18-086626237 18086626237	2693528373@qq.com	China	2973	56
SPIRO PHARMA		eric_feng1954@126.com	China	9248	55

Supplier	Advantage
TargetMol Chemicals Inc.	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
TargetMol Chemicals Inc.	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Amadis Chemical Company Limited	58
Haoyuan Chemexpress Co., Ltd.	61
DebyeTec.com Inc.	56
SPIRO PHARMA	55

View Lastest Price from 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-04	Necrostatin 2 852391-19-6	US $78.00-166.00 / mg		99.92%	10g	TargetMol Chemicals Inc.
	2025-05-15	Necrostatin 2 852391-19-6	US $78.00-166.00 / mg		99.92%	10g	TargetMol Chemicals Inc.

Necrostatin 2
852391-19-6
US $78.00-166.00 / mg
99.92%
TargetMol Chemicals Inc.

Necrostatin 2
852391-19-6
US $78.00-166.00 / mg
99.92%
TargetMol Chemicals Inc.

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Necrostatin 2 (5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR Necroptotic Inhibitor Necrostatin 2 R-isomer (±)-Necrostatin-2 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione (5R)- (5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione 852391-19-6