JTT-705
- CAS No.
- 211513-37-0
- Chemical Name:
- JTT-705
- Synonyms
- CS-259;JTT-705;RO4607381;Dalcetrapib;JTT705;JTT 705;Unii-3D050liq3h;JTT-705 USP/EP/BP;Dalcetrapib(JTT-705);JTT-705 (Dalcetrapib);EZSolution Dalcetrapib
- CBNumber:
- CB5299629
- Molecular Formula:
- C23H35NO2S
- Molecular Weight:
- 389.59
- MDL Number:
- MFCD06407886
- MOL File:
- 211513-37-0.mol
- MSDS File:
- SDS
| Melting point | 63-63.5 °C |
|---|---|
| Boiling point | 528.9±33.0 °C(Predicted) |
| Density | 1.06±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | insoluble in H2O; ≥12.7 mg/mL in DMSO; ≥80.2 mg/mL in EtOH |
| form | solid |
| pka | 13.95±0.70(Predicted) |
| FDA UNII | 3D050LIQ3H |
SAFETY
Risk and Safety Statements
| Hazard statements | H413 |
|---|
JTT-705 price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 89450 | Dalcetrapib ≥98% | 211513-37-0 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 89450 | Dalcetrapib ≥98% | 211513-37-0 | 5mg | $227 | 2024-03-01 | Buy |
| Cayman Chemical | 89450 | Dalcetrapib ≥98% | 211513-37-0 | 10mg | $403 | 2024-03-01 | Buy |
| Cayman Chemical | 89450 | Dalcetrapib ≥98% | 211513-37-0 | 50mg | $1065 | 2024-03-01 | Buy |
| Usbiological | 007488 | Dalcetrapib | 211513-37-0 | 5mg | $566 | 2021-12-16 | Buy |
JTT-705 Chemical Properties,Uses,Production
Uses
Dalcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor. Dalcetrapib is a drug undergoing trials for the treatment of cardiovascular disease, dyslipidemia, peripheral arterial disease (PAD).
Uses
Dalcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor. Dalcetrapib is a drug undergoing trials for the treatment of cardiovascular disease, dyslipidemia, peripheral arterial disease (PA D).
Definition
ChEBI: 2-methylpropanethioic acid S-[2-[[[1-(2-ethylbutyl)cyclohexyl]-oxomethyl]amino]phenyl] ester is an anilide.
Biological Activity
cholesteryl ester transfer protein (cetp) is a plasma protein that transfers neutral lipids among the lipoproteins. its most important action is the exchange of cholesteryl esters in high-density lipoprotein (hdl) for triglycerides in very low-density lipoprotein. thus, cetp is a potentially atherogenic protein, and its atherogenicity has been supported by many studies. dalcetrapib is a novel inhibitors of cetp.
in vitro
dalcetrapib achieved 50% inhibition of cetp activity in human plasma at a concentration of 6 μm. the mechanism of action was considered to involve the formation of a disulfide bond between the thiol form of dalcetrapib and the cysteine residue at position 13 (cys13) of cetp. [1].
in vivo
dalcetrapib achieved 95% inhibition of cetp activity in male japanese white rabbits at an oral dose of 30 mg/kg. it increased the plasma hdl cholesterol level by 27% and 54%, respectively, when given at oral doses of 30 or 100 mg/kg once a day for 3 days to male japanese white rabbits [1].
target
rhCETP
IC 50
6 μm for cetp inhibition in human plasma
References
[1] shinkai h, maeda k, yamasaki t, okamoto h, uchida i. bis(2-(acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and s-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein. j med chem. 2000;43(19):3566-72.
[2] fayad za, mani v, woodward m, kallend d, abt m, burgess t, fuster v, ballantyne cm, stein ea, tardif jc, rudd jh, farkouh me, tawakol a. safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-plaque): a randomised
JTT-705 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
