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GSK2982772

GSK2982772
GSK2982772 structure
CAS No.
1622848-92-3
Chemical Name:
GSK2982772
Synonyms
5184;CS-2502;GSK2982772;GSK 2982772;GSK-2982772;RIP1 inhibitor GS2982772;(S)-5-BENZYL-N-(5-METHYL-4-OXO-2,3,4,5-TETRAHYDROBENZO[B][1,4]OXAZEPIN-3-YL)-4H-1,2,4-TRIAZOLE-3-CAR;(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide;1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-
CBNumber:
CB53060417
Molecular Formula:
C20H19N5O3
Formula Weight:
377.4
MOL File:
1622848-92-3.mol

GSK2982772 Properties

Density 
1.40±0.1 g/cm3(Predicted)
pka
8.80±0.40(Predicted)
FDA UNII
T5W3M0VO9B

GSK2982772 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29230 GSK2982772 1622848-92-3 1mg $49 2021-03-22 Buy
Cayman Chemical 29230 GSK2982772 1622848-92-3 10mg $294 2021-03-22 Buy
Cayman Chemical 29230 GSK2982772 1622848-92-3 5mg $196 2021-03-22 Buy

GSK2982772 Chemical Properties,Uses,Production

Description

(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide, also known as GSK2982772, is a first-in-class receptor interacting protein 1(RIP1)-kinase specific clinical candidate for the treatment of inflammatory disease. It is an inhibitor of RIP1 that regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. It has excellent activity in blocking many TNF-dependent cellular responses. Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants. 

References

Harris, P. A., et al. "Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases." Journal of Medicinal Chemistry 60.4(2017):1247-1261.
Jeong, Jae Uk, et al. "Synthesis of ( S )-3-amino-benzo[ b ][1,4]oxazepin-4-one via Mitsunobu and S N Ar reaction for a first-in-class RIP1 kinase inhibitor GSK2982772 in clinical trials." Tetrahedron Letters 58.23(2017):2306-2308.

GSK2982772 Preparation Products And Raw materials

Raw materials

Preparation Products


GSK2982772 Suppliers

Global( 67)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
Chemia Biotechnology(Shanghai) Co., Ltd
0086-13816753574
info@chemia-pharm.com CHINA 311 58
Shandong Natural Micron Pharm Tech Co.,LTD
13752232623
info@nmpharmtech.com CHINA 2736 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58
Chengdu Henghui Pharm Tec Co. Ltd. 13540674322 15828370308
028-89481236 CHINA 121 55

View Lastest Price from GSK2982772 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-02 GSK2982772
1622848-92-3
US $1.00-1.00 / KG 1KG 98% 1lg; 2kg; 5kg; 10kg; 100kg career henan chemical co

1622848-92-3(GSK2982772)Related Search:


  • (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
  • 5184
  • GSK2982772
  • RIP1 inhibitor GS2982772
  • CS-2502
  • (S)-5-BENZYL-N-(5-METHYL-4-OXO-2,3,4,5-TETRAHYDROBENZO[B][1,4]OXAZEPIN-3-YL)-4H-1,2,4-TRIAZOLE-3-CAR
  • GSK 2982772;GSK-2982772
  • 1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-
  • (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide
  • 1622848-92-3
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