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Betaine hydrochloride

Betaine hydrochloride
Betaine hydrochloride structure
Chemical Name:
Betaine hydrochloride
Achyin;Euacid;Muriat;Acidin;ACIDOL;Acinorm;Achylin;Acidine;BET HCL;Pepsacid
Molecular Formula:
Formula Weight:
MOL File:

Betaine hydrochloride Properties

Melting point:
241-242 °C(lit.)
4223 | BETAINE
storage temp. 
room temp
H2O: 1 M at 20 °C, clear, colorless
Powder or Crystals
Colorless to white
1 (50g/l, H2O, 20℃)
Water Solubility 
64.7 g/100 mL (25 ºC)
CAS DataBase Reference
590-46-5(CAS DataBase Reference)
EWG's Food Scores
ATC code
NIST Chemistry Reference
Betaine hydrochloride(590-46-5)
EPA Substance Registry System
Betaine hydrochloride (590-46-5)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338+P337+P313-P280i-P337+P313-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36-36/37/38-20/21/22
Safety Statements  26-39-24/25-36
WGK Germany  3
RTECS  BP3136000
Autoignition Temperature 400 °C
HS Code  29239000
NFPA 704
1 0

Betaine hydrochloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14633 Betain hydrochloride for synthesis 590-46-5 100 g $19.79 2021-03-22 Buy
Sigma-Aldrich 8.14633 Betain hydrochloride for synthesis 590-46-5 1 kg $94.35 2021-03-22 Buy
Sigma-Aldrich B3501 Betaine hydrochloride ≥99% 590-46-5 1kg $115 2021-03-22 Buy
Sigma-Aldrich PHR2356 Betaine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 590-46-5 300MG $149 2021-03-22 Buy
Sigma-Aldrich 1065709 Betaine hydrochloride United States Pharmacopeia (USP) Reference Standard 590-46-5 200mg $366 2021-03-22 Buy

Betaine hydrochloride Chemical Properties,Uses,Production


Betaine hydrochloride is a vitamin-like substance that is a source of hydrochloric acid and aids the production of stomach acid. Gastric acid also helps protect the gastrointestinal tract from harmful bacteria. A normal level of gastric acid in the stomach—100,000-1,000,000 times more acidic than water—is sufficient to destroy bacteria, but some people produce deficient amounts of stomach acid, a condition that may lead to bacterial and parasitic infections of the intestines.
Betaine Hydrochloride with Pepsin
One study showed that fasting people with normal gastric acid levels in the stomach had almost no bacteria in the small in- testine, while individuals with low levels of hydrochloric acid had some bacterial colonization in the stomach.Betaine hydrochloride is therefore recommended by some medical practitioners to sustain a healthy and normal production of stomach acid, especially to those that suffer from disorders such as allergies and asthma.
Betaine hydrochloride is a synthesized chemical, and is not obtained from any plant or animal source. Gastric acid is produced by stomach cells, and is not available from any food source. Occasionally, betaine (C5H11NO2 )is recommended to reduce blood levels of homocysteine, which is associated with heart disease. This form of betaine is different from betaine hydrochlo- ride, and is available only with a doctor’s prescription.

Chemical Properties

colorless to white crystals


Betaine hydrochloride can be used as antiarteriosclerotic, hypolipaemic, hepatoprotectant.


antiprotozoal, coccidiostat


Betaine is used as gastric acidifier.naturopaths have long held that low stomach acid is a widespread problem that interferes with the digestion and absorption of nutrients. Betaine hydrochloride is one of the most common recommendations for this condi- tion. It helps make some minerals and other nutrients more absorbable, and may be especially helpful with nu- tritional supplements, which are often taken in tablets or capsules that may not be easily digested.


Betaine hydrochloride may be used as a lipotropic. Lipotropics aid in preventing the accumulation of fat in the liver, and usually help in the detoxification of metabolic wastes and toxins. They may be used to help with weight loss.
Betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria, a condition in which an abnormally low amount of hydrochloric acid is in the stomach. It has been used in preparations for the treatment of liver disorders, hypokalaemia (abnormally low levels of potassium in the blood), CO2 production in double contrast radiography, and high homocysteine. Betaine hydrochloride has also been used to treat tic douloreux (a condition which involves spasmodic pain along the course of a facial nerve), cystinuria (a hereditary defect that results in recurrent kidney stone formation), and vitiligo (a condition that is characterized by milky-white patches on otherwise normal skin).

Biological Functions

Betaine hydrochloride and pepsin are naturally occurring gastric-juice components that render nutrients available for absorption and biological acitivity. Specifically, Betaine hydrochloride is an acidic form of betaine, which promotes optimal gastric lumen acidity and pepsin is a protein-digesting enzyme that catalyzes the splitting of peptide bonds.
Betaine HCl is an excellent source of hydrochloric acid, also known as stomach acid. Supplementing with betaine HCl can be very beneficial, as insufficient production of hydrochloric acid is fairly widespread and often overlooked. Certain situations, such as normal aging, can decrease the body’s natural production of HCl.

Clinical Use

Betaine hydrochloride (pronounced beta-een) is the acid form of trimethyiglycine (TMG). It is available as an over-the-counter drug. The most common use of betaine hydrochloride is as digestive aid for people who suffer from low gastric acidity (hypochlorhydria), a common complaint in the elderly and a cause of chronic indigestion. Although such a practice is unwise. betaine hydrochloride can be of use in cases of overeating. Gourmands, in particular, suffer less discomfort after indulgences if they take betaine hydrochloride with their feasts.
Betaine hydrochloride is not only a digestive aid, but it also confers all the benefits of TMG (see next). However, betaine hydrochloride should not be used by anyone with chronic indigestion or heartburn without first seeking medical evaluation of the problem to make sure that there is not a more serious underlying condition. such as stomach ulcers. Betaine hydrochloride should be taken only with meals, and then only after first eating a few bites of food. The usual dose of betaine hydrochloride for hypochlorhydria is 500 milligrams. which is equivalent to 1.1 cubic centimeter (about a quarter teaspoon) of pharmaceutical Dilute Hydrochloric acid.

Side effects

Side effects are seldom seen, but as of 2013 betaine hydrochloride had not been through rigorous safety studies. Its safety, especially for young children, pregnant or nursing women, or those with severe liver or kidney disease, is not known.
In very high doses, betaine hydrochlorine has been associated with heartburn or burning of the stomach lining.

Drug interactions

People taking nonsteroidal anti-inflammatory drugs (NSAIDs), cortisone-like drugs, or other medications that could cause peptic ulcers should not take betaine hy- drochloride.

Purification Methods

Recrystallise the salt from EtOH. Its solubility at 25o is 65% in H2O, and 5% in EtOH. [Edsall J Am Chem Soc 66 1767 1943, Kuhn & Ruelius Chem Ber 83 420 1950, Beilstein 4 III 1127, IV 2369.]


People with a history of ulcers, heartburn, or other gastrointestinal symptoms should see a nutritionally oriented doctor before taking betaine hydrochloride, and no one should take more than 10 grains (650 mg) without a physician's recommendation. Large amounts of betaine hydrochloride can burn the lining of the stomach. If a burning sensation is experienced, betaine hydrochloride should be immediately discontinued.

Betaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Betaine hydrochloride Suppliers

Global( 374)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
Jinan Honest Pharm Co., Ltd
+86-15318812076;; CHINA 288 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20911 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8909 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29955 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897 CHINA 2712 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5912 58
Chongqing Chemdad Co.,Ltd
+86-19923101450 CHINA 4000 58

View Lastest Price from Betaine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-02 Betaine hydrochloride
US $30.00 / KG 1KG 99 5000T Baoji Guokang Healthchem co.,ltd
2021-08-14 Betaine hydrochloride
1KG 99 10tons Shijiazhuang tongyang Import and Export Co., LTD
2021-07-30 Betaine hydrochloride
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

Betaine hydrochloride Spectrum

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