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Potassium chloride

Potassium chloride
Potassium chloride
CAS No.
7447-40-7
Chemical Name:
Potassium chloride
Synonyms
KCl;ClK;OGY;Kato;Nu-K;CLK1;K-dur;K-Lor;K-Tab;Leo K
CBNumber:
CB9137176
Molecular Formula:
ClK
Formula Weight:
74.55
MOL File:
7447-40-7.mol

Potassium chloride Properties

Melting point:
770 °C(lit.)
Boiling point:
1420°C
Density 
1.98 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.334
Flash point:
1500°C
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
random crystals
color 
White
Specific Gravity
1.984
PH
5.5-8.0 (20℃, 50mg/mL in H2O)
Water Solubility 
340 g/L (20 ºC)
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.01
Merck 
14,7621
Sublimation 
1500 ºC
BRN 
1711999
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids. Protect from moisture. Hygroscopic.
InChIKey
WCUXLLCKKVVCTQ-UHFFFAOYSA-M
CAS DataBase Reference
7447-40-7(CAS DataBase Reference)
NIST Chemistry Reference
Potassium chloride(7447-40-7)
EPA Substance Registry System
Potassium chloride (KCl)(7447-40-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,C,F,Xn,T
Risk Statements  36-34-11-36/37/38-40-61-60
Safety Statements  24/25-39-26-22-23-45-36/37/39-16-36/37-53
RIDADR  UN 1824 8 / PGII
WGK Germany  1
RTECS  TS8050000
8
TSCA  Yes
HS Code  31042090
Hazardous Substances Data 7447-40-7(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 2600 mg/kg
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
Precautionary statements:
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Potassium chloride price More Price(159)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 12636 Potassium chloride puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E508, 99-100.5% (AT), ≤0.0001% Al 7447-40-7 1kg $73.9 2018-11-13 Buy
Sigma-Aldrich 12636 Potassium chloride puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E508, 99-100.5% (AT), ≤0.0001% Al 7447-40-7 6x1kg $315 2018-11-13 Buy
Alfa Aesar 010839 Potassium chloride, Puratronic?, 99.997% (metals basis) 7447-40-7 250g $489 2018-11-16 Buy
Alfa Aesar 010839 Potassium chloride, Puratronic?, 99.997% (metals basis) 7447-40-7 50g $116 2018-11-16 Buy
Strem Chemicals 93-1914 Potassium chloride, 99+% (ACS) 7447-40-7 2kg $109 2018-11-13 Buy

Potassium chloride Chemical Properties,Uses,Production

Description

Potassium chloride (KCl) is a metal halide salt that is used in a variety of areas. The dominant application of potassium chloride is to serve as a fertilizer, which offers potassium to plants and prevents them from certain diseases. Besides, it can be applied in food and medical industry. As a treatment for hypokalemia, potassium chloride pills are taken to balance the blood's potassium levels and prevent potassium deficiency in the blood. In food industry, it serves as a electrolyte replenisher and a good salt substitute for food, as well as a firming agent to give consistent texture to food, thus to strengthen its structure.

Chemical Properties

Potassium chloride, KCI, also known as potassium muriate and sylvite, is a colorless crystalline solid with a salty taste that melts at 776°C (1420 OF). It is soluble in water, but insoluble in alcohol. Potassium chloride is used in fertilizers, pharmaceuticals, photography, and as a salt substitute.

Chemical Properties

Potassium chloride occurs as odorless, colorless crystals or a white crystalline powder, with an unpleasant, saline taste. The crystal lattice is a face-centered cubic structure.

Uses

Potassium Chloride is a nutrient, dietary supplement, and gelling agent that exists as crystals or powder. it has a solubility of 1 g in 2.8 ml of water at 25°c and 1 g in 1.8 ml of boiling water. hydrochloric acid, and sodium chloride and magnesium chloride diminish its solubility in water. it is used as a salt substitute and mineral supple- ment. it has optional use in artificially sweetened jelly and preserves. it is used as a potassium source for certain types of carrageenan gels. it is used to replace sodium chloride in low-sodium foods.

Uses

potassium chloride is a laboratory reagent used to increase product viscosity in cosmetic and pharmaceutical preparations.

Uses

Potassium chloride (KCl), commonly referred to as muriate of potash, is the most common source of potash (K2O), and accounts for about 95 % of world potash production. Virtually all (90 %) commercial potash is extracted from natural sources of potassium salt deposits occurring in thin beds in large salt basins formed by the evaporation of ancient seas. Present-day salt lakes and natural brines represent about 10 % of total recoverable potash. Extraction is followed by milling, washing, screening, flotation, crystallization, refining and drying.
More than 90 % of the total KCl consumption is used for fertilizer production. Production of potassium hydroxide accounts for more than 90 % of the non-fertilizer or industrial use of KCl. KOH is also used in the production of some agricultural-grade liquid fertilizers. uses of KCl include:
  1. Potassium chloride (KCl) is inorganic salt used for making fertilizers, since the growth of many plants is limited by their potassium intake. Potassium in plants is important for the osmotic and ionic regulation, plays a key role in the water homeostasis and is closely connected with processes involved in the protein synthesis.
  2. In photography. In buffer solutions, electrode cells.
  3. Potassium chloride may be used for the preparation of phosphate buffered saline, and for the extraction and solubilization of proteins.
  4. Used in buffer solutions, medicine, scientific applications, and food processing.
  5. Used in nutritent; gelling agent; salt substitute; yeast food.
  6. food/foodstuff additives: KCl is used as a nutrient and/or dietary supplement food additive. KCl also serves as a potassium supplement of animal feed.
  7. pharmaceutical products: KCl is an important therapeutic agent, which is used mainly in the treatment of hypokalemia and associated conditions. Hypokalemia (potassium deficiency) is a potentially fatal condition in which the body fails to retain sufficient potassium to maintain health.
  8. laboratory chemicals: KCl is used in electrode cells, buffer solutions, and spectroscopy.
  9. drilling mud for oil production industry: KCl is used as conditioner in oil drilling muds and as a shale stabilizer to prevent swelling.
  10. flame retardants and fire preventing agents: KCl is used as a component in dry chemical fire extinguisher.
  11. anti-freezing agents: KCl is used to melt ice on streets and driveways.

Uses

About 4-5% of potash production is used in industrial applications (UNIDOIFDC, 1998). In 1996, the world supply of industrial grade potash was close to 1.35 Mt K2O. This industrial material is 98-99% pure, compared with the agricultural potash specification of 60% K2O minimum (equivalent to 95% KCl). Industrial potash should contain at least 62% K2O and have very low levels of Na, Mg, Ca, SO4 and Br. This high-grade potash is produced by only a few producers in worldwide.
Industrial grade potash analysis
Potassium hydroxide (KOH), also known as caustic potash, is the largestvolume K product for non-fertilizer use. It is produced by the electrolysis of industrial KCl and is widely used for manufacturing soaps, detergents, grease, catalysts, synthetic rubber, matches, dyes and insecticides. Caustic potash is also as a liquid fertilizer and as an ingredient in alkaline batteries and photographic film processing chemicals.
Potassium hydroxide is a raw material in the production of various K salts, mainly K carbonates, and also citrates, silicates, acetates, etc. Potassium carbonate confers excellent clarity to glass thus is used for most fine optical lenses, eyeglasses, fine crystal, glassware, chinaware and TV tubes. Potassium bicarbonate is used largely in the food and pharmaceutical industries.
Potash-derived compounds and salts are also used in the production of metal fluxes, cured meats, tempered steel, paper fumigants, case hardened steel, bleaching agents, baking powder, cream of tartar and beverages. Worldwide, industrial KCl is estimated to be used as follows: detergents and soaps, 30-35%; glass and ceramics, 25-28%; textiles and dyes 20-22%; chemicals and drugs, 13-15%; and other uses, 7-5% (UNIDO-IFDC, 1998).

Definition

ChEBI: A metal chloride salt with a K(+) counterion.

Production Methods

Potassium chloride occurs naturally as the mineral sylvite or sylvine; it also occurs in other minerals such as sylvinite, carnallite, and kainite. Commercially, potassium chloride is obtained by the solar evaporation of brine or by the mining of mineral deposits.

Uses

  1. Potassium chloride is a widely used reagent in biochemistry and molecular biology. It is a component of phosphate buffered saline (PBS, Product No. P 3813) and of polymerase chain reaction (PCR) buffer (50 mM KCl).
  2. KCl is also used in studies of ion transport and potassium channels.
  3. KCl is also utilized in the solubilization, extraction, purification, and crystallization of proteins.
  4. The use of KCl in the crystallization of histone core octamers has been reported.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Potassium chloride is not in general strongly reactive. Violent reaction with BrF3 and with a mixture of sulfuric acid potassium permanganate mixture . Reacts with concentrated sulfuric acid to generate fumes of hydrogen chloride.

Health Hazard

Potassium chloride is an essential constituent of the body for intracellular osmotic pressure and buffering, cell permeability, acid-base balance, muscle contraction and nerve function.
SYMPTOMS: Large doses of Potassium chloride usually induce vomiting, so acute intoxication by mouth is rare. If no pre-existing kidney damage, it is rapidly excreted. Poisoning disturbs the rhythm of heart. Large doses by mouth can cause gastrointestinal irritation, purging, weakness, and circulatory disturbances.

Fire Hazard

Flammability data is not available, but Potassium chloride is probably nonflammable.

Agricultural Uses

Muriate of potash or potassium chloride (KCl), is a major potash fertilizer. It is water soluble and is generally blended with other components to make it a multi-nutrient fertilizer. It has a higher salt index than potassium sulphate and is recommended for most crops except tobacco, potato and grapes, which are sensitive to chloride ions.

Agricultural Uses

Potassium chloride (KCl), also known as muriate of potash, is generally blended with other components to make it a multinutrient fertilizer. It is a white crystalline solid, available in fine, coarse and granular grades. It is the least expensive carrier of potassium in the fertilizer market. This important fertilizer contains about 48 to 52% plant food as potassium and about 48% chloride. Coarser potassium blends well with granular N-P compounds to form an NPK-blended multinutrient fertilizer.
At least 78 % of the potassium salts are estimated to be consumed worldwide, in the form of potassium chloride, and over 90% of all processed potassium is used as fertilizer. Muck, peat and sands are generally potassiumdeficient, whereas arid soils are mostly potassium-rich, with 448 kg/ha or more of readily available potassium.
Potassium chloride is neutral and totally watersoluble. It can be applied to all soils and crops that are not sensitive to chlorides. Soluble soil-potassium is adsorbed and retained by soil colloids and thus prevented from leaching. Roots take up potassium in the ionic form.
Potassium chloride is best applied either while sowing or prior to it. However, when soils are light or coarsetextured, the applied potassium may be lost through leaching. So, it is preferable to apply potassium in split doses. On heavy soils, the fertilizer is placed advantageously in bands, as in the case of phosphatic fertilizers.
Potassium chloride is manufactured from potash minerals or brine. Sylvinite, which is a mixture of potassium chloride and halite, is the major potash mineral used for potassium chloride manufacture. A large percentage of potassium chloride is mined and refined either by the floatation or crystallization process. Both processes, of which the floatation process is more common, involve the separation of potassium chloride from sodium chloride. Fine potassium chloride is a freeflowing material which does not cake in dry places.

Pharmaceutical Applications

Potassium chloride is widely used in a variety of parenteral and nonparenteral pharmaceutical formulations. Its primary use, in parenteral and ophthalmic preparations, is to produce isotonic solutions.
Potassium chloride is also used therapeutically in the treatment of hypokalemia.
Many solid-dosage forms of potassium chloride exist including: tablets prepared by direct compression and granulation; effervescent tablets; coated, sustained-release tablets; sustained- release wax matrix tablets;microcapsules;pellets; and osmotic pump formulations.
Experimentally, potassium chloride is frequently used as a model drug in the development of new solid-dosage forms, particularly for sustained-release or modified-release products. Potassium chloride is also used widely in the food industry as a dietary supplement, pH control agent, stabilizer, thickener, and gelling agent. It can also be used in infant formulations.

Safety Profile

A human poison by ingestion. Poison experimentally by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: nausea, blood clotting changes, carhac arrhythmias. An eye irritant. Mutation data reported. Explosive reaction with BrF3; sulfuric acid + potassium permanganate. When heated to decomposition it emits toxic fumes of K2O and Cl-.

Safety

Potassium chloride is used in a large number of pharmaceutical formulations, including oral, parenteral, and topical preparations, both as an excipient and as a therapeutic agent.
Potassium ions play an important role in cellular metabolism and imbalances can result in serious clinical effects. Orally ingested potassium chloride is rapidly absorbed from the gastrointestinal tract and excreted by the kidneys. Potassium chloride is more irritant than sodium chloride when adminstered orally, and ingestion of large quantities of potassium chloride can cause effects such as gastrointestinal irritation, nausea, vomiting, and diarrhea.
High localized concentrations of potassium chloride in the gastrointestinal tract can cause ulceration: hence the development of the many enteric-coated and wax matrix sustained-release preparations that are available.Although it is claimed that some formulations cause less ulceration than others, it is often preferred to administer potassium chloride as an aqueous solution. However, solutions have also been associated with problems, mainly due to their unpleasant taste.
Parenterally, rapid injection of strong potassium chloride solutions can cause cardiac arrest; in the adult, solutions should be infused at a rate not greater than 750 mg/hour.
Therapeutically, in adults, up to 10 g orally, in divided doses has been administered daily, while intravenously up to 6 g daily has been used.
(guinea pig, oral): 2.5 g/kg
(mouse, IP): 1.18 g/kg
(mouse, IV): 0.12 g/kg
(mouse, oral): 0.38 g/kg
(rat, IP): 0.66 g/kg
(rat, IV): 0.14 g/kg
(rat, oral): 2.6 g/kg

storage

Potassium chloride tablets become increasingly hard on storage at low humidities. However, tablets stored at 76% relative humidity showed no increase or only a slight increase in hardness.The addition of lubricants, such as 2% w/w magnesium stearate, reduces tablet hardness and hardness on aging.Aqueous potassium chloride solutions may be sterilized by autoclaving or by filtration.
Potassium chloride is stable and should be stored in a well-closed container in a cool, dry place.

Purification Methods

Dissolve it in conductivity water, filter it, and saturate it with chlorine (generated from conc HCl and KMnO4). Excess chlorine is boiled off, and the KCl is precipitated by HCl (generated by dropping conc HCl into conc H2SO4). The precipitate is washed with water, dissolved in conductivity water at 90-95o, and crystallised by cooling to about -5o. The crystals are drained at the centrifuge, dried in a vacuum desiccator at room temperature, then fused in a platinum dish under N2, cooled and stored in a desiccator. Potassium chloride has also been sublimed in a stream of pre-purified N2 gas and collected by electrostatic discharge [Craig & McIntosh Can J Chem 30 448 1952].

Incompatibilities

Potassium chloride reacts violently with bromine trifluoride and with a mixture of sulfuric acid and potassium permanganate. The presence of hydrochloric acid, sodium chloride, and magnesium chloride decreases the solubility of potassium chloride in water. Aqueous solutions of potassium chloride form precipitates with lead and silver salts.
Intravenous aqueous potassium chloride solutions are incompatible with protein hydrolysate.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, ophthalmic preparations, oral capsules, and tablets). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

References

https://en.wikipedia.org/wiki/Potassium_chloride
https://www.drugbank.ca/drugs/DB00761
http://study.com/academy/lesson/what-is-potassium-chloride-uses-formula-side-effects.html

Potassium chloride Preparation Products And Raw materials

Raw materials

Preparation Products


Potassium chloride Suppliers

Global( 363)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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View Lastest Price from Potassium chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 Potassium chloride
7447-40-7
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-09-13 Potassium chloride
7447-40-7
US $1.00 / G 100G 99.9% 50000tons Hebei Ruishun Trade Co.,Ltd
2017-08-30 Food Grade Potassium Chloride,Pharma Grade Potassium Chloride
7447-40-7
US $10.00 / KG 25KG 99% 2000 TONS Jiangsu Kolod Food Ingredients Co.,Ltd.

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