DDR1-IN-2
- CAS No.
- 1429617-90-2
- Chemical Name:
- DDR1-IN-2
- Synonyms
- 7rh;DDR1-IN-2;7rh??(DDR1-IN-2);DDR1 Inhibitor 7rh;DDR1 Inhibitor 7rh >=98% (HPLC);DDR1 IN 2,Discoidin Domain Receptor,Inhibitor,7rh,inhibit,DDR-1-IN-2,DDR1IN2;4-Ethyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide;4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE;Benzamide, 4-ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)-
- CBNumber:
- CB53367620
- Molecular Formula:
- C30H29F3N6O
- Molecular Weight:
- 546.59
- MDL Number:
- MFCD30185014
- MOL File:
- 1429617-90-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
DDR1-IN-2 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1832 | DDR1 Inhibitor 7rh ≥98% (HPLC) | 1429617-90-2 | 5mg | $134 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1832 | DDR1 Inhibitor 7rh ≥98% (HPLC) | 1429617-90-2 | 25mg | $217.2 | 2024-03-01 | Buy |
| ChemScene | CS-0035397 | DDR1-IN-2 98.62% | 1429617-90-2 | 25mg | $740 | 2021-12-16 | Buy |
| Activate Scientific | AS117230 | DDR1-IN-2 97+% | 1429617-90-2 | 5mg | $163 | 2021-12-16 | Buy |
| ChemScene | CS-0035397 | DDR1-IN-2 98.62% | 1429617-90-2 | 5mg | $210 | 2021-12-16 | Buy |
DDR1-IN-2 Chemical Properties,Uses,Production
Uses
7rh is a useful research chemical compound.
Uses
7rh is a discoidin domain receptor 1 (DDR1) inhibitor useful in the study of similar derivatives as potential anticancer and anti-??inflammatory drugs.
General Description
DDR1 Inhibitor 7rh is a small potent kinase inhibitor of discoidin domain receptor-1 (DDR1). It inhibits the tumorigenicity of nasopharyngeal carcinoma (NPC) cells. DDR1 Inhibitor 7rh prevents the proliferation, invasion and adhesion of cancer cells.
Biochem/physiol Actions
DDR1 Inhibitor 7rh is an orally available, potent, ATP-competitive DDR1-selective inhibitor with in vitro and in vivo anti-cancer efficacy. Compound 7rh is a potent, high affinity (Kd =0.6 nM), ATP-competitive inhibitor against discoidin domain-containing receptor 1 (DDR1; IC50 = 6.8 nM, [ATP] = 100 nM) with significantly reduced potency toward 455 other kinases, including DDR2, Bcr-abl, and c-Kit (IC50 = 101.4 nM, 355 nM and >10 μM, respectively). Inhibitor 7rh reduces DDR1 expression/phosphorylation and downstream signaling in a dose-dependent manner (0.1-2 μM; NCI-H23 NSCLCs), effectively suppressing human cancer cells proliferation (IC50 from 38 nM/K562 to 2.98 μM/NCI-H460) and colony formation (IC50 = 0.56 μM/NCI-H23). Inhibitor 7rh is orally availabe in rats and mice (T1/2 = 15.53 h; Tmax = 4.25 h; Cmax = 1867.5 μg/L, F = 67.4%; 25 mg/kg; rats) and displays in vivo efficacy against Kras (LSLG12Vgeo) tumor growth in mice (50 mg/kg/day p.o.).
storage
Store at -20°C
DDR1-IN-2 Preparation Products And Raw materials
Raw materials
Preparation Products
DDR1-IN-2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39010 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4334 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9556 | 58 |