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TACRINE HYDROCHLORIDE

TACRINE HYDROCHLORIDE Structure
TACRINE HYDROCHLORIDE structure
CAS No.
1684-40-8
Chemical Name:
TACRINE HYDROCHLORIDE
Synonyms
TACRINE;COGNEX;TACRINE HCL;hydroaminacrine;ci970;ROMOTAL;tenakrin;THA Dihydrate;Romotal Dihydrate;Tenakrin Dihydrate
CBNumber:
CB5402661
Molecular Formula:
C13H15ClN2
Molecular Weight:
234.72
MDL Number:
MFCD00012657
MOL File:
1684-40-8.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:06
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TACRINE HYDROCHLORIDE Properties

Melting point 280-284 °C(lit.)
storage temp. Inert atmosphere,2-8°C
solubility Soluble in aqueous buffers
pka pKa 9.8 (Uncertain)
form Crystalline solid
CAS DataBase Reference 1684-40-8(CAS DataBase Reference)
FDA UNII 4966RNG0BU
ATC code N06DA01
EPA Substance Registry System Tacrine hydrochloride (1684-40-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H302-H331-H301-H315-H319-H335
Precautionary statements  P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  T,Xn
Risk Statements  25-36/37/38-20/22
Safety Statements  26-36-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  AR9532500
HazardClass  6.1(a)
PackingGroup  II
Toxicity LD50 intravenous in mouse: 5600ug/kg
NFPA 704
0
4 0

TACRINE HYDROCHLORIDE price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J60070 Tacrine hydrochloride 1684-40-8 5g $215.65 2024-03-01 Buy
Cayman Chemical 70240 Tacrine (hydrochloride) 1684-40-8 1000mg $36 2024-03-01 Buy
Cayman Chemical 70240 Tacrine (hydrochloride) 1684-40-8 5000mg $117 2024-03-01 Buy
Tocris 0965 Tacrine hydrochloride ≥99%(HPLC) 1684-40-8 100 $73 2021-12-16 Buy
Usbiological 256797 Tacrine hydrochloride 1684-40-8 100mg $296 2021-12-16 Buy
Product number Packaging Price Buy
J60070 5g $215.65 Buy
70240 1000mg $36 Buy
70240 5000mg $117 Buy
0965 100 $73 Buy
256797 100mg $296 Buy

TACRINE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Tacrine is the first therapeutic launched specifically for the treatment of Alzheimer's disease which affects four million people in the US alone. Clinically significant improvement in cognition has been demonstrated in the patients with Alzheimer's disease. Although the cause of Alzheimer's disease is not understood, degeneration of cholinergic neurons is thought to be a primary factor in the development and progression of the disease. Tacrine is a reversible acetylcholinesterase inhibitor that presumably acts centrally by elevating the acetylcholine level in the cerebral cortex and by slowing degradation of acetylcholine from intact cholinergic neurons. While tacrine improves the symptoms of Alzheimer's disease, the underlining cause of the dementing process is not altered. It has also been suggested that the beneficial effects of tacrine may be due to its multiple effects on several neurotransmitter systems.

Description

Tacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and decreases depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Formulations containing tacrine have been used clinically in the treatment of Alzheimer’s disease.

Chemical Properties

Pale Yellow Solid

Originator

NIH (U.S.A.)

Uses

A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholi

Uses

A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.

Uses

anticholinesterase, cognitive adjuvant, K channel blocker

brand name

Cognex (Sciele).

General Description

Tacrine hydrochloride,1,2,3,4-tetrahydro-9-aminoacridine hydrochloride (THA,Cognex), is a reversible cholinesterase inhibitor that hasbeen used in the treatment of Alzheimer disease for severalyears. The drug has been used to increase the levels of AChin these patients on the basis of observations from autopsiesthat concentrations of ChAT and AChE are markedly reducedin the brain, whereas the number of muscarinic receptorsis almost normal. The use of the drug is not withoutcontroversy, as conflicting results on efficacy have been reported.The drug has been used in mild-to-moderateAlzheimer dementia.

General Description

Yellow needles (from concentrated hydrochloric acid); white powder. pH of 1.5% solution: 4.5-6. Bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

TACRINE HYDROCHLORIDE is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides . Neutralize bases in slightly exothermic reactions.

Fire Hazard

Flash point data for TACRINE HYDROCHLORIDE are not available; however, TACRINE HYDROCHLORIDE is probably combustible.

Biological Activity

Potent cholinesterase inhibitor, a cognition enhancer in vivo .

Metabolism

Tacrine is extensively metabolized by CYP450 to at least three metabolites. The major metabolite, 1-hydroxy-tacrine, is active. Its elimination half-life is between 1.5 and 4 hours, with metabolites being are excreted via the urine.

TACRINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

TACRINE HYDROCHLORIDE Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10326 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9320 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20356 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Supplier Advantage
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Hubei Ipure Biology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
CD Chemical Group Limited 		58
Alfa Chemistry 		58

View Lastest Price from TACRINE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TACRINE HYDROCHLORIDE pictures 2024-04-17 TACRINE HYDROCHLORIDE
1684-40-8
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
TACRINE HYDROCHLORIDE USP/EP/BP pictures 2021-08-14 TACRINE HYDROCHLORIDE USP/EP/BP
1684-40-8
 US $1.10 / g 1g 0.999 100 Tons min Dideu Industries Group Limited
TACRINE HYDROCHLORIDE pictures 2021-07-02 TACRINE HYDROCHLORIDE
1684-40-8
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

TACRINE HYDROCHLORIDE Spectrum

TACRINE HYDROCHLORIDE(1684-40-8)MSTACRINE HYDROCHLORIDE(1684-40-8)1HNMRTACRINE HYDROCHLORIDE(1684-40-8)13CNMRTACRINE HYDROCHLORIDE(1684-40-8)IR1TACRINE HYDROCHLORIDE(1684-40-8)IR2

1684-40-8(TACRINE HYDROCHLORIDE)Related Search:

2',6'-DiMethylcarbonylphenyl-10-sulfopropylacridiniuM-9-carboxylate 4'-NHS Ester Butyrylcholinesterase 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE TACRINE HYDROCHLORIDE 6,7-DICHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE
5-Chloro-1,2,3,4-tetrahydro-9-morpholinoacridine hydrochloride 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HCL HYDRATE Centbucridine BIS(7)-TACRINE 9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE
TACRINE HYDROCHLORIDE HYDRATE 9-AMINO-6-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE 9-AMINO-6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROACRIDIN-1(2H)-ONE 1-Acridinol, 1,2,3,4-tetrahydro-6-chloro-9-((phenylmethyl)amino)- 1,2,3,4-Tetrahydro-9-((2-(bis(2-chloroethyl)amino)ethyl)amino)acridine dihydrochloride
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE BIS 1,7-HEPTYLENE DIHYDROCHLORIDE 9-AMINO-6-CHLORO-3,4-DIHYDROACRIDIN-1(2H)-ONE 1,2,3,4-TETRAHYDRO-6-CHLORO-9-(N-D,L-ALPHA-LIPOOYLANIDOPROPYL)-AMINO-ACRIDINE

1of4

1,2,3,4-tetrahydro-9-acridinaminmonohydrochloride 1,2,3,4-tetrahydro-9-aminoacridinehydrochloride 1,2,3,4-tetrahydro-9-amino-acridinmonohydrochloride 9-amino-1,2,3,4-tetrahydro-acridinhydrochloride 1,2,3,4-TETRAHYDRO-9-ACRYDINAMINEHCLMONOHYDRATE 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINEHYDROCHLORIDEMONOHYDRATE 1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate 9-Amino-1,2,3,4-tetrahydroacridine, Hydrochloride Dihydrate Hydroaminacrine Dihydrate Romotal Dihydrate Tacrine Hydrochloride Dihydrate Tenakrin Dihydrate THA Dihydrate 1,2,3,4-tetrahydroacridin-9-amine monohydrochloride 9-AMINO-1,2,3,4-TETRAHYDROACRIDINEHYDROC HLORIDE HY 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDRO -CHLORIDE (TACRINE, TH 9-Amino-1,2,3,4-tetrahydroacridine hydrate hydrochloride tacrine hydrochloride, Tetrahydroaminacrine hydrate hydrochloride, THA hydrate hydrochloride 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate,THA hydrochloride hydrate, Tetrahydroaminacrine hydrochloride hydrate, tacrine hydrochloride Tacrine Hydrochloride (500 mg) Tacrine Hydrochloride, Monohydrate, USP 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE ROMOTAL TACRINE HYDROCHLORIDE ci970 tacrinhydrochloride tenakrin tetrahydroaminacrin 1,2,3,4-TETRAHYDRO-5-AMINOACRIDINE HYDROCHLORIDE 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE, MONOHYDROCHLORIDE tacrine monohydrochloride TACRINE HYDROCHLORIDE USP/EP/BP Tacrine Hydrochloride (1642700) TACRINE TACRINE HCL hydroaminacrine COGNEX 1684-40-8 C13H14N2HCl AMINE A to C Biochemicals and Reagents BioChemical Cholinesterase, acetyl Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates COGNEX Chemical Amines Amines Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals Acetylcholine receptor