ACETYL-DL-CARNITINE HYDROCHLORIDE
- CAS No.
- 2504-11-2
- Chemical Name:
- ACETYL-DL-CARNITINE HYDROCHLORIDE
- Synonyms
- TIMTEC-BB SBB003214;Acetyl-DL-carnitineHCl;acetyldl-carnitinechloride;d,l-acetylcarnitin-chlorid;(+/-)-ACETYLCARNITINE CHLORIDE;ACETYL-DL-CARNITINE HYDROCHLORIDE;acetyl-dl-carnitine hcl crystalline;Acetyl-DL-carnitinehydrochloridecrystalline;(RS)-3-Acetoxy-4-(trimetylammino)butyrate hydrochloride;(2-acetyloxy-3-carboxypropyl)-trimethylazanium,chloride
- CBNumber:
- CB5440058
- Molecular Formula:
- C9H18ClNO4
- Molecular Weight:
- 239.7
- MDL Number:
- MFCD00080826
- MOL File:
- 2504-11-2.mol
| Melting point | 181 - 183°C |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble to 100 mM in water |
| Stability | Hygroscopic |
| CAS DataBase Reference | 2504-11-2(CAS DataBase Reference) |
| FDA UNII | 2WQN168TM5 |
ACETYL-DL-CARNITINE HYDROCHLORIDE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1509 | Acetyl-DL-carnitine hydrochloride | 2504-11-2 | 250mg | $165 | 2024-03-01 | Buy |
| Sigma-Aldrich | A1509 | Acetyl-DL-carnitine hydrochloride | 2504-11-2 | 1g | $469 | 2024-03-01 | Buy |
| TRC | A172003 | (±)-AcetylcarnitineChloride | 2504-11-2 | 100mg | $180 | 2021-12-16 | Buy |
| TRC | A172003 | (±)-AcetylcarnitineChloride | 2504-11-2 | 10mg | $45 | 2021-12-16 | Buy |
| ApexBio Technology | B6273 | (±)-Acetylcarnitinechloride | 2504-11-2 | 100mg | $125 | 2021-12-16 | Buy |
ACETYL-DL-CARNITINE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
(±)-Acetylcarnitine Chloride is a drug absorption-enhancing agent in the gastrointestinal tract.
Biological Activity
(±)-acetylcarnitine chloride is an agonist for cholinergic.acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-acetylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Biochem/physiol Actions
Weak cholinergic receptor agonist; intermediate in lipid metabolism.
Purification Methods
Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]
ACETYL-DL-CARNITINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ACETYL-DL-CARNITINE HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
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| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
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| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
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