3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT
- CAS No.
- 133525-01-6
- Chemical Name:
- 3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT
- Synonyms
- AZT-G;AZT GLUCURONIDE;Zidovudine Glucuronide;AZT Glucuronide SodiuM Salt;zidovudine beta-D-glucuronide;Zidovudine Glucuronide SodiuM Salt;3'-Azido-3'-deoxythymidine β-D-glucuronide;3'-azido-3'-deoxythymidine B-D-*glucuronide sodiu;3'-AZIDO-3'-DEOXYTHYMIDINE O-D-GLUCURONIDE SODIUM SALT;3'-Azido-3'-deoxy-5'-O-β-D-glucopyranuronosylthymidine
- CBNumber:
- CB5452909
- Molecular Formula:
- C16H20N5NaO10
- Molecular Weight:
- 465.35
- MDL Number:
- MFCD02091675
- MOL File:
- 133525-01-6.mol
- MSDS File:
- SDS
| Melting point | 158-163°C |
|---|---|
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly, Heated, Sonicated), Methanol (Very Slightly, Heated), Water (Slightly) |
| form | Solid |
| color | White to Light Yellow |
| Stability | Hygroscopic |
| FDA UNII | CD09F5JM6T |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18679 | 3'-Azido-3'-deoxythymidine β-D-glucuronide (sodium salt) ≥95% | 133525-01-6 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 18679 | 3'-Azido-3'-deoxythymidine β-D-glucuronide (sodium salt) ≥95% | 133525-01-6 | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 18679 | 3'-Azido-3'-deoxythymidine β-D-glucuronide (sodium salt) ≥95% | 133525-01-6 | 10mg | $258 | 2024-03-01 | Buy |
| TRC | A825050 | 3''-Azido-3''-deoxythymidineβ-D-glucuronide,SodiumSalt | 133525-01-6 | 25mg | $460 | 2021-12-16 | Buy |
| Biosynth Carbosynth | NA06316 | 3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt | 133525-01-6 | 25mg | $485 | 2021-12-16 | Buy |
3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT
Biological Activity
3'-azido-3'-deoxythymidine β-d-glucuronide is the metabolite of zidovudine, a nucleoside reverse transcriptase inhibitor.zidovudine, an antiretroviral medication used to prevent and treat hiv, is recommended for use with other antiretroviral and may be also used to prevent mother to child spread during birth or after a needlestick injury or other potential exposure.
in vitro
3'-azido-3'-deoxythymidine β-d-glucuronide is a metabolite of zidovudine, formed by direct conjugation by udp-glucuronosyltransferase 2b7. the azido group of both zidovudine and 3'-azido-3'-deoxythymidine β-d-glucuronide could be reduced to an amino group by cytochrome cyp3a, cyp2a6, or cyp2b1, forming 3’-amino-3’-deoxythymidine (amt) and amt glucuronide, respectively [1].
in vivo
animal study found that zidovudine-treated rats had higher systolic blood pressure, greater heart weight and greater interventricular septum thickness. electron microscopy revealed mitochondrial swelling in myocardiocytes in zidovudine-treated rats. reduced response to contractile stimuli and enhanced relaxation in response to charbacol were observed in the aortic rings of zidovudine-treated rats. the aortic myocytes of zidovudine-treated rats contained apparently unaffected ultrastructural features, but light microscopy suggested their marked enlargement [2].
References
[1] walsky, r. l.,bauman, j.n.,bourcier, k., et al. optimized assays for human udp-glucuronosyltransferase (ugt) activities: altered alamethicin concentration and utility to screen for ugt inhibitors. drug metabolism and disposition 40(5), 1051-1065 (2012).
[2] ruga e, bova s, nussdorfer g, mazzocchi g, rebuffat p, milanesi o, cargnelli g. zidovudine-induced alterations in the heart and vascular smooth muscle of the rat. cardiovasc res. 2003 oct 15;60(1):147-55.
3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10026 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; | sales@mreda.com.cn | China | 21450 | 58 |