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PROTAC ER Degrader-3

PROTAC ER Degrader-3 Structure
PROTAC ER Degrader-3 structure
CAS No.
2158322-29-1
Chemical Name:
PROTAC ER Degrader-3
Synonyms
PROTAC ER Degrader-3;Carbamic acid, N-[(1S)-2-[[(3S,4S)-7-cyano-2,3,4,5-tetrahydro-5-[4-[[[2-[2-[2-[[2-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-2-oxoethoxy]ethoxy]ethyl]amino]carbonyl]benzoyl]-1-[(2-methoxy-1-naphthalenyl)methyl]-4-methyl-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]-1-methyl-2-...
CBNumber:
CB55419815
Molecular Formula:
C71H77N7O12
Molecular Weight:
1220.43
MDL Number:
MFCD32067948
MOL File:
2158322-29-1.mol
Last updated:2023-05-21 10:59:17
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PROTAC ER Degrader-3 Properties

Boiling point 1264.4±65.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 9.38±0.15(Predicted)

PROTAC ER Degrader-3 Chemical Properties,Uses,Production

Description

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC comprises an antibody conjugated via a linker to a PROTAC. PAC extracts from patent WO2017201449A1, compound LP2. PAC is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

References

[1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.

PROTAC ER Degrader-3 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC ER Degrader-3 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9445 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1290 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Chaolan Chemical Technology Center 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58

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PROTAC ER Degrader-3 Carbamic acid, N-[(1S)-2-[[(3S,4S)-7-cyano-2,3,4,5-tetrahydro-5-[4-[[[2-[2-[2-[[2-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-2-oxoethoxy]ethoxy]ethyl]amino]carbonyl]benzoyl]-1-[(2-methoxy-1-naphthalenyl)methyl]-4-methyl-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]-1-methyl-2-... 2158322-29-1