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TK05

TK05 Structure
TK05 structure
CAS No.
1245734-61-5
Chemical Name:
TK05
Synonyms
TK05;TK-05,TK05;Benzoic acid, 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)-
CBNumber:
CB55821449
Molecular Formula:
C31H25ClN2O5
Molecular Weight:
540.99
MDL Number:
MFCD32062774
MOL File:
1245734-61-5.mol
Last updated:2023-05-05 08:29:07
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TK05 Properties

Boiling point 769.1±60.0 °C(Predicted)
Density 1.348±0.06 g/cm3(Predicted)
pka 2.56±0.36(Predicted)

TK05 Chemical Properties,Uses,Production

Biological Activity

TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1]. TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1]. TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1].

References

[1]. Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16.

TK05 synthesis

69565-54-4
1245734-61-5
Synthesis of TK05 from (4-CHLORO-PHENYL)-CYCLOPROPYLMETHYL-AMINE HYDROCHLORIDE

TK05 Preparation Products And Raw materials

Raw materials

(4-CHLORO-PHENYL)-CYCLOPROPYLMETHYL-AMINE HYDROCHLORIDE

Preparation Products

TK05 Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223 psaitong@jm-bio.com China 29834 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
RD International Technology Co., Limited 18988968278 sales@ubiochem.com China 9146 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
TK05 TK-05,TK05 Benzoic acid, 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)- 1245734-61-5