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ChemicalBook CAS DataBase List TK05

TK05 synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 12 h / 80 °C
2: isopropylmagnesium chloride / tetrahydrofuran; methanol / -80 °C
3: manganese(IV) oxide / 60 °C
4: sodium hydroxide / water / 0.5 h / 60 °C

References:

Kleinschmidt, Thea K.;Haraldsson, Martin;Basavarajappa, Devaraj;Lundeberg, Erik;Thulasingam, Madhuranayaki;Ekoff, Maria;Fauland, Alexander;Lehmann, Christoph;Kahnt, Astrid S.;Lindbom, Lennart;Haeggstr?m, Jesper Z. [Journal of Pharmacology and Experimental Therapeutics,2015,vol. 355,# 1,p. 108 - 116]