N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE
- CAS No.
- 113558-89-7
- Chemical Name:
- N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE
- Synonyms
- E-4031;E-4031 (free base);E-4031 DIHYDROCHLORIDE;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide;4'-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL] METHANESULFONANILIDE, 2HCL;Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-;N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE
- CBNumber:
- CB5749205
- Molecular Formula:
- C21H27N3O3S
- Molecular Weight:
- 401.52
- MDL Number:
- MFCD01754739
- MOL File:
- 113558-89-7.mol
- MSDS File:
- SDS
N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Properties
Boiling point | 561.7±60.0 °C(Predicted) |
---|---|
Density | 1.243±0.06 g/cm3(Predicted) |
storage temp. | RT |
solubility | Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml). |
form | White solid. |
pka | 7.11±0.10(Predicted) |
color | White |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months. |
FDA UNII | 1L1K8X5DF9 |
N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 324470 | E-4031 - CAS 113558-89-7 - Calbiochem A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC?? = 10 nM). | 113558-89-7 | 5MG | $362 | 2024-03-01 | Buy |
Tocris | 1808 | E-4031dihydrochloride ≥98%(HPLC) | 113558-89-7 | 10 | $209 | 2021-12-16 | Buy |
Tocris | 1808 | E-4031dihydrochloride ≥98%(HPLC) | 113558-89-7 | 50 | $862 | 2021-12-16 | Buy |
Usbiological | 255211 | E-4031 dihydrochloride | 113558-89-7 | 10mg | $466 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0015408 | N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 95.00% | 113558-89-7 | 5MG | $496.02 | 2021-12-16 | Buy |
N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Description
E-4031 (113558-89-7) is a selective hERG potassium channel blocker. Inhibits the rapid delayed-rectifier K+ current (IKr). Class III antiarrhythmic agent. Cell permeable.
Definition
ChEBI: E-4031 is a sulfonamide.
in vitro
it has been reported that e-4031 could induce eads or tdp, and such induction correlated with a significant increase in variability of repolarization. in addition, e-4031 at 0.1 um was able to significantly prolong cycle length, action potential duration, and depolarized maximum diastolic potential. e-4031could also reduce the upstroke velocity of the action potential as well as the diastolic depolarization rate [1].
in vivo
animal study showed that e-4031 at 0.01 and 0.1 mg/kg could provide effective in-vitro plasma concentrations to significantly inhibit ikr and thus delayed the repolarization beyond the initiation of diastole, leading to the inversion of electro-mechanical coupling, which provides an ideal proarrhythmic substrate [2]. another sutdy found that e-4031 could prolong qt interval and ari in all lv layers, though the magnitude of prolongation was greatest in mid, particularly during bradycardia [3].
IC 50
7.7 nm for herg
References
1) Ficker et al. (2002), The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo gene (HERG) mutations; J. Biol. Chem., 277 4989 2) Wettwer et al. (1991), Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysical parameters; J. Cardiovasc. Pharmacol., 17 480
N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
ChengDu SinoStandards Bio-Tech Co.,Ltd. , | 028-83243028 19136088901 | sinostandards@163.com | China | 5044 | 58 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
Xianning Shen Lan Biomedical Research and Development Co., Ltd. | 18171815831 | 1341138380@qq.com | China | 2769 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4030 | 58 |
MeiKe medicine technology (Foshan City) Co., LTD | 18029359586 | sales@mkmeditech.com | China | 790 | 58 |
N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Spectrum
113558-89-7(N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE)Related Search:
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