(-)-THALIDOMIDE
- CAS No.
- 841-67-8
- Chemical Name:
- (-)-THALIDOMIDE
- Synonyms
- NSC 91730;(–)-Thalidomide;(-)-THALIDOMIDE;(S)-(-)-THALIDOMIDE;Thalidomide (S)-Isomer;(S)Thalidomide,(S) Thalidomide;6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid;N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide;(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN;(-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide
- CBNumber:
- CB5762707
- Molecular Formula:
- C13H10N2O4
- Molecular Weight:
- 258.23
- MDL Number:
- MFCD00210219
- MOL File:
- 841-67-8.mol
| Melting point | 269-271°C |
|---|---|
| Boiling point | 401.48°C (rough estimate) |
| Density | 1.2944 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO: soluble |
| pka | 10.70±0.40(Predicted) |
| form | solid |
| color | white |
| optical activity | [α]23/D 62.6°, c = 2 in DMF(lit.) |
| FDA UNII | TG87FSR590 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H360 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-22 | |||||||||
| Safety Statements | 53-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TI4925050 | |||||||||
| NFPA 704 |
|
(-)-THALIDOMIDE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T150 | (?)-Thalidomide >98%, solid | 841-67-8 | 10mg | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | T150 | (?)-Thalidomide >98%, solid | 841-67-8 | 25mg | $271 | 2024-03-01 | Buy |
| Sigma-Aldrich | T150 | (?)-Thalidomide >98%, solid | 841-67-8 | 100mg | $762 | 2024-03-01 | Buy |
| TRC | T338860 | (S)-(-)-Thalidomide | 841-67-8 | 100mg | $725 | 2021-12-16 | Buy |
| TRC | T338860 | (S)-(-)-Thalidomide | 841-67-8 | 50mg | $400 | 2021-12-16 | Buy |
(-)-THALIDOMIDE Chemical Properties,Uses,Production
Chemical Properties
Needles
Uses
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
Uses
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative
Definition
ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre.
General Description
Thalidomide is a stereoisomer, which exists in two enantiomeric states. The S enantiomer is teratogenic. Thalidomide consists of two linked rings, a phthalimide and glutarimide ring.
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits the biosynthesis of tumor necrosis factor α (TNF-α), which is essential for inflammatory response. It is an anti-emetic drug and is used to treat morning sickness in pregnant women. Thalidomide is also used to treat leprosy, multiple myeloma, Crohn′s disease and human immunodeficiency virus (HIV) infection. Thalidomide also inhibits angiogenesis. It is associated with several diseases such as, peripheral neuropathy, facial palsies, Duane syndrome and autism.
(-)-THALIDOMIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
View Lastest Price from (-)-THALIDOMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-02 | (S)-thalidomide
841-67-8
|
US $0.00 / mg | 25mg | >99.00% | 25mg | Xian confluore Biological Technology Co., Ltd. |
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- (S)-thalidomide
841-67-8
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.