clorexolone
- CAS No.
- 2127-01-7
- Chemical Name:
- clorexolone
- Synonyms
- Klorex;12833 RP;Nefrolan;M&B 8430;RP 12833;RP-12833;Flonatril;clorexolone;Chlorexolone;clorexolone USP/EP/BP
- CBNumber:
- CB5875104
- Molecular Formula:
- C14H17ClN2O3S
- Molecular Weight:
- 328.818
- MDL Number:
- MFCD00867311
- MOL File:
- 2127-01-7.mol
- MSDS File:
- SDS
| Melting point | 266-268° |
|---|---|
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly, Heated), Methanol (Very Slightly, Heated) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | Q2PLT3FS05 |
| ATC code | C03BA12 |
clorexolone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C327080 | Chlorexolone | 2127-01-7 | 50mg | $1455 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 55521 | Chlorexolone | 2127-01-7 | 50mg | $2200 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005529 | CLOREXOLONE 95.00% | 2127-01-7 | 5MG | $500.68 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 55521 | Chlorexolone | 2127-01-7 | 5mg | $650 | 2021-12-16 | Buy |
clorexolone Chemical Properties,Uses,Production
Originator
Speciatensol,Specia,France,1966
Uses
Chlorexolone is a low-ceiling sulfonamide diuretic.
Uses
Chlorexolone is a sulfonamide based antibiotic.
Definition
ChEBI: Clorexolone is an organic molecular entity.
Manufacturing Process
4-Chlorophthalimide (263 g) was reacted in amyl alcohol (2.6 l) with
cyclohexylamine (143.5 g, 1 mol) at reflux temperature for 16 hours to give
N-cyclohexyl-4-chlorophthalimide (250 g, 66%) as a solid, MP 134°C to
136°C.
N-Cyclohexyl-1-chlorophthalimide (250 g) was dissolved in glacial acetic acid
(2.5 l), concentrated hydrochloric acid (555 ml) and tin (278 g) were added
and the suspension was heated on a steam bath for 16 hours. The cooled
solution was filtered and concentrated to dryness in vacuo to give a white
solid. This solid was dissolved in water and the precipitated oil extracted with
chloroform. The chloroform solution was dried and concentrated in vacuo to
give a solid which, after recrystallization, yielded 5-chloro-2-
cyclohexylisoindolin-1-one (43%), MP 140°C to 142°C.
5-Chloro-2-cyclohexylisoindolin-1-one (102.9 g) was dissolved in concentrated
sulfuric acid (665 ml); potassium nitrate (723 g) in concentrated sulfuric acid
(166 ml) was added at 0 °C. The reaction mixture was allowed to warm to
room temperature and stirred at 25°C for 12 hours. The reaction mixture was
poured onto ice to give a cream solid which, after recrystallization from
benzene, gave 5-chloro-2-cyclohexyl-6-nitroisoindolin-1-one (46.7 g, 44%) as
a white solid, MP 164°C to 168°C.
5-Chloro-2-cyclohexyl-6-nitroisoindolin-1-one (93.9 g) was reduced in
concentrated hydrochloric acid (1,970 ml) with stannous chloride (376 g). The
reaction temperature rose to 70°C. The resulting solution was cooled in ice
and filtered. The product was washed well with water, filtered and dried to
give 6-amino-5-chloro-2-cyclohexylisoindolin-1-one (74.1 g, 87.6%) which,
after recrystallization from benzene, had a MP of 216°C to 218°C.
6-Amino-5-chloro-2-cyclohexylisoindolin-1-one (42.5 g) was dissolved in
concentrated hydrochloric acid (425 ml) and the solution diazotized by the
addition of sodium nitrite (21.25 g) in water (125 ml). The resulting
diazonium salt solution was added to a solution of liquid sulfur dioxide (93 ml)
in glacial acetic acid (243 ml) containing cuprous chloride (2.25 g). A yellow
solid was precipitated; this was filtered off, washed, dried and recrystallized
from benzene to give 5-chloro-2-cyclohexylisoindolin-1-one-6-sulfonyl chloride
(45 g, 80%) as a cream solid, MP 171°C to 174°C.
This sulfonyl chloride (23.7 g) was reacted with liquid ammonia (237 ml) to
give 5-chloro-2-cyclohexyl-6-sulfamoylisoindolin-1-one (14.2 g, 53%). MP
259°C to 261°C.
Therapeutic Function
Diuretic
clorexolone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10194 | 62 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
View Lastest Price from clorexolone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-10 | clorexolone USP/EP/BP
2127-01-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- clorexolone USP/EP/BP
2127-01-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited