SB269970 HCl
- CAS No.
- 261901-57-9
- Chemical Name:
- SB269970 HCl
- Synonyms
- SB-269970A;SB269970 HCl USP/EP/BP;SB269970 HClSB269970 HCl;SB269970 HCl (SB-269970A);SB269970 hydrochloride, >=98%;(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1);(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride;SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
- CBNumber:
- CB5972915
- Molecular Formula:
- C18H28N2O3SHCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD03788020
- MOL File:
- 261901-57-9.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble10mg/mL, clear (warmed to 60 °C) |
| form | powder |
| FDA UNII | DKP3XMW7KV |
SB269970 HCl price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S7389 | SB-269970 hydrochloride powder, ≥98% (HPLC) | 261901-57-9 | 5mg | $353 | 2024-03-01 | Buy |
| Sigma-Aldrich | S7389 | SB-269970 hydrochloride powder, ≥98% (HPLC) | 261901-57-9 | 25mg | $1230 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.06415 | SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem | 261901-57-9 | 10MG | $196 | 2023-06-20 | Buy |
| Cayman Chemical | 17081 | SB-269970 (hydrochloride) ≥98% | 261901-57-9 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 17081 | SB-269970 (hydrochloride) ≥98% | 261901-57-9 | 10mg | $184 | 2024-03-01 | Buy |
SB269970 HCl Chemical Properties,Uses,Production
Description
The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.
Uses
SB 269970A is a selective 5-HT7 receptor antagonist.
General Description
A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
Biochem/physiol Actions
Primary Target5-HT
storage
+4°C
References
[1] hagan j j, price g w, jeffrey p, et al. characterization of sb-269970-a, a selective 5-ht7 receptor antagonist. british journal of pharmacology, 2000, 130(3): 539-548.
SB269970 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
SB269970 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4874 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Suzhou yacoo science co.,Ltd | 0512-87182056 18013166090 | lingling.qi@yacoo.com.cn | China | 7300 | 60 |