ChemicalBook >제품 카탈로그 >생화학 공학>억제제>신경 신호 전달>5-HT 수용체 길항제>SB269970 HCl

SB269970 HCl

SB269970 HCl 구조식 이미지

카스 번호:: 261901-57-9

상품명:: SB269970 HCl

동의어(영문):: SB-269970A;SB269970 HCl USP/EP/BP;SB269970 HClSB269970 HCl;SB269970 HCl (SB-269970A);SB269970 hydrochloride, >=98%;(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1);(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride;SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride

CBNumber:: CB5972915

분자식:: C18H28N2O3SHCl

포뮬러 무게:: 0

MOL 파일:: 261901-57-9.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 56

SB269970 HCl 속성

저장 조건: 2-8°C

용해도: H2O: 용해성 10mg/mL, 투명(60°C로 가열)

물리적 상태: 가루

안전

WGK 독일	3

SB269970 HCl C화학적 특성, 용도, 생산

개요

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT_7A antagonist (pK_i = 8.9) that demonstrates >50-fold binding selectivity over 5-HT_5A and >250-fold selectivity over 5-HT₁, 5-HT₂, 5-HT₄, 5-HT₆, adrenergic α₁, dopamine D₂, and dopamine D₃ receptors. It is also reported to block adrenergic α₂ receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT₇ receptor in the study of schizophrenia-like cognitive deficits.

용도

SB 269970A is a selective 5-HT7 receptor antagonist.

일반 설명

A selective 5-HT₇ receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT₇ receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT₇ antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT_5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT_7A, 5-HT_5A and 5-HT_1B).

SB269970 HCl 준비 용품 및 원자재

원자재

준비 용품

SB269970 HCl 공급 업체

글로벌( 56)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4874	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 18521732826;	market@aladdin-e.com	China	25015	65
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Suzhou yacoo science co.,Ltd	0512-87182056 18013166090	lingling.qi@yacoo.com.cn	China	7300	60