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Madecassoside

Madecassoside structure

CAS No.: 34540-22-2

Chemical Name:: Madecassoside

Synonyms: RederMic;MADECASSOIDE;MADECASSOSIDE;Asiaticoside A;MADECASSOSIDE(P);MADECASSOSIDE hplc;Madecassoside (8CI);MADECASSOSIDE WITH HPLC;Madecassoside (Asiaticoside A);Madecassoside, froM Centella asiatica

CBNumber:: CB6210654

Molecular Formula:: C48H78O20

Molecular Weight:: 975.12

MDL Number:: MFCD03411893

MOL File:: 34540-22-2.mol

Last updated:2024-05-14 11:56:19

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Madecassoside Properties

Melting point	220-223 °C
Boiling point	1043.6±65.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: soluble1mg/mL, clear, colorless
form	powder
pka	12.50±0.70(Predicted)
color	white to off-white
Stability	Hygroscopic
InChIKey	BNMGUJRJUUDLHW-CIZDPPTDSA-N
LogP	-1.338 (est)
EWG's Food Scores	1
FDA UNII	CQ2F5O6YIY

SAFETY

Risk and Safety Statements

Safety Statements	24/25
WGK Germany	3
RTECS	YU9555000
HS Code	29389090

Madecassoside price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M6949	Madecassoside from Centella asiatica ≥95% % (HPLC)	34540-22-2	10mg	$185	2024-03-01	Buy
Sigma-Aldrich	M6949	Madecassoside from Centella asiatica ≥95% % (HPLC)	34540-22-2	50mg	$225.6	2024-03-01	Buy
Cayman Chemical	11855	Madecassoside ≥98%	34540-22-2	5mg	$57	2024-03-01	Buy
Cayman Chemical	11855	Madecassoside ≥98%	34540-22-2	10mg	$107	2024-03-01	Buy
Cayman Chemical	11855	Madecassoside ≥98%	34540-22-2	25mg	$249	2024-03-01	Buy

Product number	Packaging	Price	Buy
M6949	10mg	$185	Buy
M6949	50mg	$225.6	Buy
11855	5mg	$57	Buy
11855	10mg	$107	Buy
11855	25mg	$249	Buy

Madecassoside Chemical Properties,Uses,Production

Description

Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.

Chemical Properties

Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM)

Uses

Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment.

Definition

ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.

Mechanism of action

Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1].

References

[1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608.

Madecassoside Preparation Products And Raw materials

Raw materials

Preparation Products

Madecassoside Suppliers

Global( 291)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6008	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	260	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18226	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	1125	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	346	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	1856	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55

Supplier	Advantage
Shaanxi Pioneer Biotech Co., Ltd .	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
BINBO BIOLOGICAL CO.,LTD	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from Madecassoside manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-14	Madecassoside 34540-22-2	US $48.00 / kg	1kg	99%	5000kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-05-11	Madecassoside 34540-22-2	US $0.00-0.00 / kg	0.10000000149011612kg	≥98%	20tons	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-05-09	Centella Asiatica Extract Madecassoside 34540-22-2	US $0.00 / kg	1kg	99%	10000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd

Madecassoside
34540-22-2
US $48.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Madecassoside
34540-22-2
US $0.00-0.00 / kg
≥98%
Chongqing Zhihe Biopharmaceutical Co., Ltd.

Centella Asiatica Extract Madecassoside
34540-22-2
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Madecassoside Spectrum

Madecassoside(34540-22-2)MS

34540-22-2(Madecassoside)Related Search:

Asiaticoside Centella asiatica extract Total Of Triterpenes PROPYLENE GLYCOL BUTYL ETHER METHYL 13-METHYLTETRADECANOATE

1,12-OCTADECANEDIOL isobutoxypropanol 6-O-BETA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE isohexadecanoic acid 2-Ethyl-1,3-hexanediol

MONOLAURIN MONOCAPRYLIN Isopropyl-cyclohexanecarboxylic acid METHYL 15-HYDROXYPENTADECANOATE 15-HYDROXYPENTADECANOIC ACID

N-PENTADECANOIC ACID ETHYL ESTER ETHYL 2,2-DIETHYLBUTYRATE 1,3-DIISOPROPYLCYCLOHEXANE

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MADECASSOIDE MADECASSOSIDE O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate MADECASSOSIDE(P) MADECASSOSIDE hplc Asiaticoside A glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)- Urs-12-en-28-oicacid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D- 2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester RederMic MADECASSOSIDE WITH HPLC Madecassoside, froM Centella asiatica Madecassoside, 98%, from Centella asiatica Madecassoside, 98%, from Centella asiatica (L.) Urb. Madecassoside (Asiaticoside A) Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)- Madecassoside (8CI) (1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate Centella Asiatica Extract Madecassoside 34540-22-2 C48H78O20 Inhibitors The group of Asiaticoside chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Saponins