- Madecassoside
-
- $0.00 / 1kg
-
2024-04-26
- CAS:34540-22-2
- Min. Order: 0.10000000149011612kg
- Purity: ≥98%
- Supply Ability: 20tons
- Madecassoside
-
- $8.00 / 1kg
-
2024-04-23
- CAS:34540-22-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- Madecassoside
-
- $0.00 / 1kg
-
2024-04-22
- CAS:34540-22-2
- Min. Order: 1kg
- Purity: 99.8%
- Supply Ability: 1000 kg
|
| | Madecassoside Basic information |
| Product Name: | Madecassoside | | Synonyms: | MADECASSOIDE;MADECASSOSIDE;O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate;O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate;MADECASSOSIDE(P);MADECASSOSIDE hplc;Asiaticoside A;glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)- | | CAS: | 34540-22-2 | | MF: | C48H78O20 | | MW: | 975.12 | | EINECS: | 252-076-1 | | Product Categories: | Inhibitors;The group of Asiaticoside;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Saponins | | Mol File: | 34540-22-2.mol |  |
| | Madecassoside Chemical Properties |
| Melting point | 220-223 °C | | Boiling point | 1043.6±65.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: soluble1mg/mL, clear, colorless | | pka | 12.50±0.70(Predicted) | | form | powder | | color | white to off-white | | Stability: | Hygroscopic | | InChIKey | BNMGUJRJUUDLHW-CIZDPPTDSA-N | | LogP | -1.338 (est) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | YU9555000 | | HS Code | 29389090 |
| | Madecassoside Usage And Synthesis |
| Description | Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity. | | Chemical Properties | Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM) | | Uses | Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment. | | Definition | ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities. | | Mechanism of action | Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1]. | | References | [1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608. |
| | Madecassoside Preparation Products And Raw materials |
|