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ChemicalBook >> CAS DataBase List >>3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Structure
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one structure
CAS No.
545445-44-1
Chemical Name:
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms
5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone;in-4-yL;Apixaban-1;HSK00001094;Apixaban Impurity H;Apixaban Impurity P;RSYY(Apremilast)-36;Apixaban Intermediates;Apixaba inretMediate B;Apixaban Intermediate 2
CBNumber:
CB62534569
Molecular Formula:
C20H25N3O3
Molecular Weight:
355.43
MDL Number:
MFCD19440881
MOL File:
545445-44-1.mol
MSDS File:
SDS
Last updated:2023-09-07 16:59:03
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3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Properties

Melting point >199°C (dec.)
Boiling point 625.0±55.0 °C(Predicted)
Density 1.267
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 3.25±0.20(Predicted)
color Pale Beige
InChI InChI=1S/C20H25N3O3/c24-19-5-1-2-10-22(19)16-6-8-17(9-7-16)23-11-3-4-18(20(23)25)21-12-14-26-15-13-21/h4,6-9H,1-3,5,10-15H2
InChIKey SCVWQFDPLBFZAP-UHFFFAOYSA-N
SMILES C1(=O)N(C2=CC=C(N3CCCCC3=O)C=C2)CCC=C1N1CCOCC1

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M732788 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1 2.5g $100 2021-12-16 Buy
American Custom Chemicals Corporation CHM0389373 3-MORPHOLINO-1-(4-(2-OXOPIPERIDIN-1-YL)PHENYL)-5,6-DIHYDROPYRIDIN-2(1H)-ONE 95.00% 545445-44-1 5MG $497.22 2021-12-16 Buy
AK Scientific W6875 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1 25g $667 2021-12-16 Buy
AK Scientific W6875 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1 5g $201 2021-12-16 Buy
Ambeed A893718 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one 95% 545445-44-1 100g $228 2021-12-16 Buy
Product number Packaging Price Buy
M732788 2.5g $100 Buy
CHM0389373 5MG $497.22 Buy
W6875 25g $667 Buy
W6875 5g $201 Buy
A893718 100g $228 Buy

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties,Uses,Production

Uses

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy can be used as an organic synthesis intermediate, mainly used in laboratory research and development and chemical production processes.

Synthesis

Synthesis_545445-44-1
2 g compound C (compound Ib) and 50 ml acetonitrile were added into a three-necked flask to obtain a turbid solution. The turbid solution was stirred and cooled to 0?? C. in an ice bath. 1.75 g (6 eq) sodium hydroxide was added and stirred in the ice bath for 10 min. Then 1.9 ml of 5-chloro-valeryl chloride (2 eq) (diluted with 2 ml acetonitrile) was dropwise added while controlling the temperature to 0-5?? C. After completing the addition, the ice bath was removed and the temperature was naturally raised to 30?? C. The reaction was performed for 5 hours. After observing the absence of the starting material and the intermediate state of the reaction, the reaction solution was cooled to 0?? C. in an ice bath, and adjusted to a neutral pH with 6 N of hydrochloric acid. The reaction solution was concentrated to dryness, pulpifying for 1 hour after adding 8 ml saturated sodium bicarbonate solution, and filtered to obtain 2.29 g yellow solid. Yield: 87.5%. Purity: 95.3% (HPLC). EI-MS (m/z): 355.2. HNMR (400 MHz, DMSO, ppm) |?7.32 (d, J=8.8 Hz, 2H), 7.26 (d, J=8.8 Hz, 2H), 5.71 (t, J=4.8 Hz, 1H), 3.72-3.69 (m, 2H), 3.65-3.63 (m, 4H), 3.60-3.57 (m, 2H), 2.79-2.77 (m, 4H), 2.44-2.41 (m, 2H), 2.40-2.39 (m, 2H), 1.88-1.82 (m, 4H).

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one synthesis

4509-90-4
1267610-26-3
545445-44-1
Synthesis of 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one from 5-Bromovaleryl chloride and 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 2-Piperidone 3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE
1-(4-Nitrophenyl)-2-piperidinone 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 5-Bromovaleryl chloride

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Preparation Products

Apixaban Impurity 51

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Suppliers

Global( 432)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Jianfeng Chemical Co., Ltd
0531-88110457; +8615562555968 info@pharmachemm.com China 222 58
Shanghai Rochi Pharmaceutical Co.,Ltd.
21-38751876 +8615000076078 info@rochipharma.com China 431 58
Jinan Million Pharmaceutical Co., Ltd
+86-531-68659554 +8613031714605 info@millionpharm.com China 154 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Supplier Advantage
Jinan Jianfeng Chemical Co., Ltd
58
Shanghai Rochi Pharmaceutical Co.,Ltd.
58
Jinan Million Pharmaceutical Co., Ltd
58
Henan Bao Enluo International TradeCo.，LTD 		58
Hangzhou ICH Biofarm Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

View Lastest Price from 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one pictures 2024-04-26 3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
545445-44-1
 US $20.00 / KG 1KG 98% 20 tons Speranza Chemical Co., Ltd.
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one pictures 2024-04-26 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
545445-44-1
 US $2.00 / kg 1kg 99% 1200KG/M Jinan Million Pharmaceutical Co., Ltd
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one pictures 2024-04-26 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
545445-44-1
 US $100.00-60.00 / kg 100kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD

545445-44-1(3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one)Related Search:

Apixaban IMpurity 5 (BMS-591329-01) 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide ethyl 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester Apixaban IMpurity 6
Apixaban 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1-(4-Nitrophenyl)-2-piperidinone 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 1,3-bis(4-bromophenyl)propan-2-one Apixaban IMpurity(BMS-778960-01) Apixaban-13C-D3
(4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) 1-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide

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5-morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-2,3-dihydropyridin-6-one 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) HSK00001094 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Apixaba inretMediate B Apixaban Intermediate B Apixaban Intermediate 2 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one Apixaban Impurity H Apixaban Intermediates Apixaban Impurity P 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one (Apixaban) 5,6-Dihydro-3-(morpholinyl)-1[4-(2-oxo-1- piperidinyl)phenyl]-2(1H)-pyridinone Apixaban-1 5,6-dihydro-3-(4-morpholine)-1-[4-(2-oxy-1-piperidyl) phenyl ]-2(1 H)-pyridone -1-[4-(2-oxopiperidin-1-yL in-4-yL 2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]- ]-5,6-dihydro-1H-pyridin-2-one 5, 6-dihydro-3 -(4-morpholine)-1-[4-(2-oxo-1-piperidyl) phenyl]-2(1H) -pyridinone ApixabanGF Impurity 1 ABCDEFGHJKL APIXABAN CAS 503612-47-3 INTERMEDIATES ，3-Morpholino-1-(4-(2-oxopiperidin-1- yl)phenyl)-5,6-dihydropyridin-2(1H)- oneethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate Apixaban intermediates，5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2- oxo-1-piperidinyl)phenyl]-2(1H)- pyridinone Apixaban Dihydro pyridenone 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phen... Impurity of apixaban383 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl) 3-(4-Morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-5,6-dihydro-2(1H)-pyridinone 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone 2(1H)-Quinolinone,3,4-dihydro-13-hydroxy- RSYY(Apremilast)-36 5,6-Dihydro-3-morpholino-1-(4-(2-oxopiperidin-1-phenyl)pyridin-2(1H)-one 5,6-Dihydro-3-Morpholino-1-(4-(2-oxo Piperidin-1-yl) Ph)Py)2(1H) one 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dhydropyridin-2(1H)-one Apixaban morpholine lactum impurity 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6- dihydropyridin-2(1H)-one 3-(morpholin-4-yl)-1-[4-(2-oxopiperidin-1-yl)phenyl]-1,2,5,6-tetrahydropyridin-2-one 545445-44-1