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RO-32-0432

RO-32-0432 structure

CAS No.: 151342-35-7

Chemical Name:: RO-32-0432

Synonyms: RO-32-0432;Ro 31-0432;RO 32-0432 HCL;RO 32-0432 HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI, HCL;BISINDOLYLMALEIMIDE XL, HCL;BISINDOYLMALEIMIDE XI HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI HYDROCHLORIDE;Ro 32 0432 hydrochloride,Ro 320432 hydrochloride;BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]

CBNumber:: CB6262512

Molecular Formula:: C28H28N4O2

Molecular Weight:: 452.55

MDL Number:: MFCD01319127

MOL File:: 151342-35-7.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:17

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RO-32-0432 Properties

Boiling point	712.2±60.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMSO: soluble
form	solid
pka	7.91±0.60(Predicted)
color	orange

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	3822000000

RO-32-0432 price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	1587	Ro32-0432hydrochloride ≥99%(HPLC)	151342-35-7	1	$221	2021-12-16	Buy
Usbiological	044610	Bisindolylmaleimide XI Hydrochloride	151342-35-7	1mg	$320	2021-12-16	Buy
ApexBio Technology	B6798	Ro32-0432hydrochloride	151342-35-7	1mg	$332	2021-12-16	Buy

Product number	Packaging	Price	Buy
1587	1	$221	Buy
044610	1mg	$320	Buy
B6798	1mg	$332	Buy

RO-32-0432 Chemical Properties,Uses,Production

Uses

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl ammatory responses in vivo.

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .

RO-32-0432 Preparation Products And Raw materials

Raw materials

Preparation Products

RO-32-0432 Suppliers

Global( 53)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Jinan Ruisi Pharmaceutical Technology Co., LTD	0531-69900633 18340090523	changyuan20@163.com	China	1717	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky (shanghai) International Co.,Ltd	60
EMMX Biotechnology LLC	60
Jinan Ruisi Pharmaceutical Technology Co., LTD	58
MedBioPharmaceutical Technology Inc	58
TargetMol Chemicals Inc.	58
ApexBio Technology	58

151342-35-7(RO-32-0432)Related Search:

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RARECHEM AN KA 0813 RO-32-0432

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RO-32-0432 RO 32-0432 HCL RO 32-0432 HYDROCHLORIDE BISINDOLYLMALEIMIDE XI, HCL BISINDOLYLMALEIMIDE XI HYDROCHLORIDE BISINDOLYLMALEIMIDE XL, HCL BISINDOYLMALEIMIDE XI HYDROCHLORIDE 2-[8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, HCL 2-(8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL)-3-(1-METHYLINDOL-3-YL)MALEIMIDE HYDROCHLORIDE (S)-3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 1H-Pyrrol-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropy rido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-, (S)- Bisindoylmaleimide XI: 2-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl)-3-(1-methylindol-3-yl)maleimide 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 3-[8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride Ro 31-0432 BisindolylMaleiMide XI . hydrochloride [Ro 32-0432] 1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)- Ro 32 0432 hydrochloride,Ro 320432 hydrochloride 151342-35-7 C28H28N4O2HCl C28H28N4O2ClH inhibitor