Methyl 6-chloro-3-Methylpyrazine-2-carboxylate
- CAS No.
- 1166831-45-3
- Chemical Name:
- Methyl 6-chloro-3-Methylpyrazine-2-carboxylate
- Synonyms
- METHYL 6-CHLORO-3-...;Methyl 6-chloro-3-Methylpyrazine-2-carboxylate;6-Chloro-3-methyl-pyrazine-2-carboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 6-chloro-3-methyl-, methyl ester
- CBNumber:
- CB62659079
- Molecular Formula:
- C7H7ClN2O2
- Molecular Weight:
- 186.6
- MDL Number:
- MFCD26127384
- MOL File:
- 1166831-45-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H335-H319-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
Methyl 6-chloro-3-Methylpyrazine-2-carboxylate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-W022877 | Methyl6-chloro-3-methylpyrazine-2-carboxylate | 1166831-45-3 | 250mg | $173 | 2021-12-16 | Buy |
| ChemScene | CS-W022877 | Methyl6-chloro-3-methylpyrazine-2-carboxylate | 1166831-45-3 | 100mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-W022877 | Methyl6-chloro-3-methylpyrazine-2-carboxylate | 1166831-45-3 | 1g | $430 | 2021-12-16 | Buy |
| Ambeed | A243080 | Methyl6-chloro-3-methylpyrazine-2-carboxylate 97% | 1166831-45-3 | 100mg | $76 | 2021-12-16 | Buy |
| Ambeed | A243080 | Methyl6-chloro-3-methylpyrazine-2-carboxylate 97% | 1166831-45-3 | 250mg | $150 | 2021-12-16 | Buy |
Methyl 6-chloro-3-Methylpyrazine-2-carboxylate Chemical Properties,Uses,Production
Synthesis
1166831-47-5
1166831-45-3
The general procedure for the synthesis of methyl 6-chloro-3-methylpyrazine-2-carboxylate from the compound (CAS:1166831-47-5) is as follows:Preparation of intermediate 64-3 (methyl 6-chloro-3-methylpyrazine-2-carboxylate): intermediate 64-4 (314 mg, 1.87 mmol) was reacted with phosphorochloridic acid (2.088 mL, 22.40 mmol) in a The suspension formed was stirred and reacted at 90 °C for 70 min. Subsequently, the reaction mixture was slowly added dropwise to water (20 mL) over a period of 2-3 hours, during which the temperature was kept below 40 °C by external cooling. Upon completion of the reaction, extraction was carried out with dichloromethane (DCM, 5 x 50 mL), the organic layers were combined and dried with anhydrous magnesium sulfate (MgSO4). The dried organic phase was filtered and concentrated to give a yellow oil. The crude product was purified by fast silica gel column chromatography with an elution gradient of 0 to 20% ethyl acetate (EtOAc)/isohexane. The pure grades were collected and concentrated to dryness to give the final title compound methyl 6-chloro-3-methylpyrazine-2-carboxylate (142 mg, 40.8% yield) as a white solid. Its nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, CDCl3) data were as follows: δ 2.76 (3H, s), 3.94 (3H, s), 8.56 (1H, s); Mass Spectrum (m/z): 187 (M + H)+.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10610 - 10629
[2] Patent: WO2009/81195, 2009, A1. Location in patent: Page/Page column 158-159
Methyl 6-chloro-3-Methylpyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Kohn & Shawn Pharmatech Co.,Ltd | 0931-4190454 13893344397 | sales@kyxpharma.com | China | 310 | 55 |
| Dtchem Laboratories,（Gan Su）Co.,Ltd. | 18993966060 | sales@techbiochem.com | China | 795 | 61 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 13651849907; | xinyu_shi@jwypharmlab.com.cn | China | 12035 | 58 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 5000 | 55 |
View Lastest Price from Methyl 6-chloro-3-Methylpyrazine-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-19 | Methyl 6-chloro-3-Methylpyrazine-2-carboxylate
1166831-45-3
|
US $1.00 / KG | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
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- Methyl 6-chloro-3-Methylpyrazine-2-carboxylate
1166831-45-3
- US $1.00 / KG
- 99.0%
- Career Henan Chemical Co