Bosutinib Monohydrate
- CAS No.
- 918639-08-4
- Chemical Name:
- Bosutinib Monohydrate
- Synonyms
- bosutinib hydrate;Bosutinib Monohydrate;Bosutinib MonohydrateQ: What is Bosutinib Monohydrate Q: What is the CAS Number of Bosutinib Monohydrate;4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile hydrate
- CBNumber:
- CB62728577
- Molecular Formula:
- C26H31Cl2N5O4
- Molecular Weight:
- 548.47
- MDL Number:
- MFCD29920031
- MOL File:
- 918639-08-4.mol
form | Solid |
---|---|
color | White to off-white |
FDA UNII | 844ZJE6I55 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS09 |
---|---|
Signal word | Warning |
Hazard statements | H400-H410-H317 |
Precautionary statements | P273-P391-P501-P273-P391-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
Bosutinib Monohydrate price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Biosynth Carbosynth | FB145112 | Bosutinib monohydrate | 918639-08-4 | 100mg | $120 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB145112 | Bosutinib monohydrate | 918639-08-4 | 250mg | $200 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB145112 | Bosutinib monohydrate | 918639-08-4 | 1g | $400 | 2021-12-16 | Buy |
AK Scientific | 4958BB | Bosutinibmonohydrate | 918639-08-4 | 500mg | $455 | 2021-12-16 | Buy |
Bosutinib Monohydrate Chemical Properties,Uses,Production
Definition
ChEBI: A hydrate that is the monohydrate form of anhydrous bosutinib.
Clinical Use
Bosulif ® (Bosutinib hydrate), also known as (SKI-606), is a novel 4-phenylamino-3-quinolinecarbonitrile kinase inhibitor approved for treatment of adults with chronic, accelerated, or blast phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+CML). Bosutinib is an orally-dosed, dual Src/Abl kinase inhibitor which provides an alternative treatment to patients exhibiting immunity to imatinib and other kinase inhibitors utilized for this treatment. In contrast to competitor tyrosine inhibitors, bosutinib inhibits autophosphorylation of both Srs and Abl kinases, leading to decreased cell growth and apoptosis. Bosutinib was originally developed by Wyeth and continues to be marketed by Pfizer after the merger of Wyeth and Pfizer in 2009.
Synthesis
Several synthetic routes to bosutinib have been reported, including synthetic work for scale up and processing to obtain pure salt forms of bosutinib for pharmaceutical applications.56-59 The current manufacturing route begins with reaction of 2-methoxy-5-nitrophenol (36) and 1-bromo-3- chloropropane (37) to provide aryl chloroether 38 in 82% yield. Reaction of 38 with Nmethylpiperazine (39) and NaI in refluxing DME provided the functionalized aryl-nitro-piperazine 40 (77% yield), which was converted directly to aniline 41 under hydrogenolysis conditions. Aniline 41 was then reacted with triethyl orthoformate and aryl cyanoamide 42, which was generated in one step from 2,4-dichloro-5-methoxy-aniline (44), 1,3-diisopropylcabodiimide (DIC), and cyanoacetic acid (45) under refluxing conditions, to yield advanced intermediate 43 (93% over 2 steps). Finally, conversion of 43 to bosutinib was facilitated by a POCl3-promoted cyclization in the presence of sulfolane. As shown in Scheme 8, employment of carefully optimized conditions for the isolation of bosutinib hydrate (VII) provided material in 75-82% yields and >99% purity.
Bosutinib Monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Jinghao Pharmaceutical Co.,Ltd | +86-21-68900963 | sales@jinghaopharma.com | CHINA | 153 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15394 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from Bosutinib Monohydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | Bosutinib Monohydrate
918639-08-4
|
US $2.00 / kg | 1kg | 99% | ask | Career Henan Chemical Co |
- Bosutinib Monohydrate
918639-08-4
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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