Revefenacin
- CAS No.
- 864750-70-9
- Chemical Name:
- Revefenacin
- Synonyms
- Revefenacin;TD-4208;1-(2-(4-((4-carbamoylpiperidin-1-yl)methyl)-N-methylbenzamido)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate;CPDD1221;REVENACIN;GSK1160724;Raffinazine;TD 4208;TD4208;Revefenacin Crude;Revefenacin / TD4208
- CBNumber:
- CB63054398
- Molecular Formula:
- C35H43N5O4
- Molecular Weight:
- 597.75
- MDL Number:
- MFCD28386316
- MOL File:
- 864750-70-9.mol
| Boiling point | 777.5±60.0 °C(Predicted) |
|---|---|
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 125 mg/mL (209.12 mM) |
| pka | 13.34±0.70(Predicted) |
| InChIKey | FYDWDCIFZSGNBU-UHFFFAOYSA-N |
| SMILES | C(OC1CCN(CCN(C(=O)C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)C)CC1)(=O)NC1=CC=CC=C1C1=CC=CC=C1 |
| FDA UNII | G2AE2VE07O |
| ATC code | R03BB08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Revefenacin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 464649 | Revefenacin | 864750-70-9 | 1mg | $425 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005717 | TD-4208 95.00% | 864750-70-9 | 5MG | $500.2 | 2021-12-16 | Buy |
| ChemScene | CS-7743 | Revefenacin 99.78% | 864750-70-9 | 2mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-7743 | Revefenacin 99.78% | 864750-70-9 | 5mg | $192 | 2021-12-16 | Buy |
| ChemScene | CS-7743 | Revefenacin 99.78% | 864750-70-9 | 10mg | $312 | 2021-12-16 | Buy |
Revefenacin Chemical Properties,Uses,Production
Description
Revefenacin is a synthetic anticholinergic that is prescribed for the treatment of chronic obstructive pulmonary disease (COPD).
Uses
Revefenacin is used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both. It is an anticholinergic drug that helps the muscles around the airways in the lungs stay relaxed to prevent symptoms such as wheezing, coughing, chest tightness, and shortness of breath.
Application
Revefenacin is an FDA-approved anticholinergic drug, a new tertiary amine biphenylcarbamate agent that also belongs to the long-acting muscarinic antagonist (LABA) family. It has the effect of relaxing the muscles around the airways of the lungs to make breathing easier. The structurally unstable tertiary amide produces a "soft drug" site, allowing rapid systemic clearance and minimising systemically mediated adverse effects. It can be used to treat symptoms such as wheezing, shortness of breath, cough and chest tightness in patients with chronic obstructive pulmonary disease (COPD: a group of diseases affecting the lungs and airways, including chronic bronchitis and emphysema).
brand name
Yupelri
Side effects
Common adverse reactions in clinical trials (1%-10%) were headache, nasopharyngitis, upper respiratory tract infection, back pain, bronchitis, dizziness, and hypertension.
Synthesis
After heating reaction between compound 133 and isocyanates 134, intermediate 135 was obtained after acidification treatment, debenzylation protection and pH alkalinity adjustment, intermediate 137 was obtained by reductive ammonification reaction with 136, de--cbz protection, and then amide product 139 was obtained by condensation reaction, and then prodrug molecule Revefenacin was obtained by reductive ammonification reaction with 140.
Revefenacin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Aupone Pharmaceutical Co.Ltd. | +86-28-+86-28-87843998-6060-6060 +8618631098571 | lijiaqi@aupone.com | China | 43 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Biopole Pharmatech Co., Ltd. | +8615151475053 | biopole@163.com | China | 37 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
Related articles
- How to synthesize Revefenacin?
- Revefenacin is a new M3 muscarinic receptor antagonist, which could prevent acetylcholine from binding with the muscarinic rec....
- Dec 22，2023
View Lastest Price from Revefenacin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-06 | Revefenacin
864750-70-9
|
US $0.00 / g | 1g | 99.99%HPLC | 200kg | Biopole Pharmatech Co., Ltd. | |
 |
2024-01-02 | Revefenacin
864750-70-9
|
US $75.00-750.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2023-11-01 | Revefenacin
864750-70-9
|
US $0.00-0.00 / kg | 1kg | 99.0%min | 800kg | Hangzhou ICH Biofarm Co., Ltd |
-
- Revefenacin
864750-70-9
- US $0.00 / g
- 99.99%HPLC
- Biopole Pharmatech Co., Ltd.
-
- Revefenacin
864750-70-9
- US $75.00-750.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Revefenacin
864750-70-9
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd