Irofulven
- CAS No.
- 920014-72-8
- Chemical Name:
- Irofulven
- Synonyms
- RM-493;BIM-22493;IRC-022493);Setmelanodide;Sermelanotide;Setmelanotide (RM-493);RM-493; BIM-22493; IRC-022493);Setmelanotide (RM-493) trifluoroacetate salt;Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2;L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide
- CBNumber:
- CB63159918
- Molecular Formula:
- C49H68N18O9S2
- Molecular Weight:
- 1117.32
- MDL Number:
- MFCD30532719
- MOL File:
- 920014-72-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Setmelanotide >98%(HPLC) | orb1941004 | 5mg | $330 |
| Setmelanotide >98%(HPLC) | orb1941004 | 10mg | $490 |
| Setmelanotide >98%(HPLC) | orb1941004 | 25mg | $870 |
| Setmelanotide >98%(HPLC) | orb1941004 | 50mg | $1380 |
| Setmelanotide 99.93% | orb1708548 | 1mg | $90 |
| Density | 1.54±0.1 g/cm3(Predicted) |
|---|---|
| pka | 12.82±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| Sequence | Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2(Disulfide bond) |
| InChIKey | HDHDTKMUACZDAA-JFHGRQLZNA-N |
| FDA UNII | N7T15V1FUY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Irofulven price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb1941004 | Setmelanotide >98%(HPLC) | 920014-72-8 | 5mg | $330 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1941004 | Setmelanotide >98%(HPLC) | 920014-72-8 | 10mg | $490 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1941004 | Setmelanotide >98%(HPLC) | 920014-72-8 | 25mg | $870 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1941004 | Setmelanotide >98%(HPLC) | 920014-72-8 | 50mg | $1380 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1708548 | Setmelanotide 99.93% | 920014-72-8 | 1mg | $90 | 2026-05-06 | Buy |
Irofulven Chemical Properties,Uses,Production
Uses
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].
in vivo
Inhibition of refeeding after an overnight fast by Setmelanotide is dependent on functional MC4R, and does not require MC3R. BIM-22493 acutely improves glucose homeostasis. Lepob/Lepob mice treated with BIM-22493 exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum glucose and HOMA-IR values[1].
Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2].
References
[1] Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. DOI:10.1016/j.peptides.2009.07.012
[2] Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7. DOI:10.2337/db12-0598
Irofulven Preparation Products And Raw materials
Raw materials
Preparation Products
Irofulven Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Linyi Changqing Chemical Co., LTD | +86-0532-55729510 +86-15853232676 | marketing@echemi.com | China | 288 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| LEON (NANJING) BIOTECHNOLOGY CO., LTD. | +8615051830413 | sales.njleonbiotech@gmail.com | China | 5482 | 58 |
| Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 | info@millionpharm.com | China | 214 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2514 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
View Lastest Price from Irofulven manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-15 | Irofulven
920014-72-8
|
US $1.00-1.00 / kg | 0.0001kg | 99% | 50kg | Jinan Million Pharmaceutical Co., Ltd | |
 |
2026-05-11 | Setmelanotide
920014-72-8
|
US $113.00-297.00 / mg | 99.93% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-05 | Setmelanotide
920014-72-8
|
US $75.00-750.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- Irofulven
920014-72-8
- US $1.00-1.00 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
-
- Setmelanotide
920014-72-8
- US $113.00-297.00 / mg
- 99.93%
- TargetMol Chemicals Inc.
-
- Setmelanotide
920014-72-8
- US $75.00-750.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
