ChemicalBook >> CAS DataBase List >>GSK864
GSK864
- CAS No.
- 1816331-66-4
- Chemical Name:
- GSK864
- Synonyms
- GSK864;GSK864,GSK-864;GSK864 >=98% (HPLC);(7S)-1-[(4-fluorophenyl)methyl]-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3,7-dicarboxamide;1H-Pyrazolo[4,3-c]pyridine-3,7-dicarboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7S)-
- CBNumber:
- CB63171695
- Molecular Formula:
- C30H31FN6O4
- Molecular Weight:
- 558.6
- MDL Number:
- MFCD30478507
- MOL File:
- 1816331-66-4.mol
- MSDS File:
- SDS
Last updated:2023-07-14 17:30:31
Boiling point | 782.9±60.0 °C(Predicted) |
---|---|
Density | 1.37±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility |
DMF:20.0(Max Conc. mg/mL);35.8(Max Conc. mM) DMSO:60.0(Max Conc. mg/mL);107.41(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);35.8(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.9(Max Conc. mM) |
pka | 11.73±0.70(Predicted) |
form | powder |
color | white to beige |
optical activity | [α]/D -66 to -76°, c = 0.5 in methanol |
GSK864 price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1757 | GSK864 ≥98% (HPLC) | 1816331-66-4 | 5MG | $312 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1757 | GSK864 ≥98% (HPLC) | 1816331-66-4 | 25MG | $1210 | 2023-06-20 | Buy |
Cayman Chemical | 18762 | GSK864 ≥98% | 1816331-66-4 | 500μg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 18762 | GSK864 ≥98% | 1816331-66-4 | 1mg | $65 | 2024-03-01 | Buy |
Cayman Chemical | 18762 | GSK864 ≥98% | 1816331-66-4 | 5mg | $266 | 2024-03-01 | Buy |
GSK864 Chemical Properties,Uses,Production
Biochem/physiol Actions
GSK864 is a cell penetrant, potent and selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) that potently inhibits intracellular 2-hydroxyglutarate (2-HG) production in HT-1080 cells. It appears that GSK864 binds to an allosteric binding site and locks WT and mutant IDH1s in a catalytically inactive conformation. GSK864 is a highly bioavailable analog of GSK321. For full characterization details, please visit the GSK864 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc
GSK864 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK864 Suppliers
Global( 56)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
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1of4
GSK864
1H-Pyrazolo[4,3-c]pyridine-3,7-dicarboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7S)-
GSK864 >=98% (HPLC)
GSK864,GSK-864
(7S)-1-[(4-fluorophenyl)methyl]-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3,7-dicarboxamide
1816331-66-4
C30H31FN6O4