MUCONOMYCIN A
- CAS No.
- 3148-09-2
- Chemical Name:
- MUCONOMYCIN A
- Synonyms
- vera;Verrucarin;NSC 126728;VERRUCARIN A;Verrucarine A;MUCONOMYCIN A;Muconomycin A, NSC 126728;16a,21-trimethyl--stereoisomer;verrucarin A from myrothecium sp;Verrucarin A from Myrothecium sp.
- CBNumber:
- CB6328001
- Molecular Formula:
- C27H34O9
- Molecular Weight:
- 502.55
- MDL Number:
- MFCD00056759
- MOL File:
- 3148-09-2.mol
| Melting point | >360° (dec) |
|---|---|
| alpha | D23 +206° (c = 1.012 in chloroform) |
| Boiling point | 512.66°C (rough estimate) |
| Density | 1.1922 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | −20°C |
| solubility | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| form | A solid |
| pka | 12.76±0.70(Predicted) |
| color | White to light yellow |
| FDA UNII | OL62X66O4I |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | WH1314900 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 2941900000 | |||||||||
| Toxicity | LD50 in mice, rats, rabbits (mg/kg): 1.5, 0.87, 0.54 i.v. (Rüsch, Sthlin) | |||||||||
| NFPA 704 |
|
MUCONOMYCIN A price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V4877 | Verrucarin A from Myrothecium sp. ≥98% (TLC) | 3148-09-2 | 1mg | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | V4877 | Verrucarin A from Myrothecium sp. ≥98% (TLC) | 3148-09-2 | 5mg | $251.4 | 2024-03-01 | Buy |
| Cayman Chemical | 29652 | Verrucarin A | 3148-09-2 | 1mg | $117 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0010016 | VERRUCARINA-MYROTHECIUM SP 95.00% | 3148-09-2 | 1MG | $703.76 | 2021-12-16 | Buy |
| ChemScene | CS-0028455 | VerrucarinA ≥98.0% | 3148-09-2 | 5mg | $750 | 2021-12-16 | Buy |
MUCONOMYCIN A Chemical Properties,Uses,Production
Uses
Verrucarin A from Myrothecium sp has been used:
- as a translation initiation inhibitor in P. falciparum W2 strain
- as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
- to test its cytotoxicity in renal cell carcinoma cells
Definition
ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.
General Description
Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.
Biochem/physiol Actions
Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells
MUCONOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
MUCONOMYCIN A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4674 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-021-61109150 | sales@tcisct.com | China | 31121 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24641 | 58 |