DECAMETHONIUM BROMIDE
- CAS No.
- 541-22-0
- Chemical Name:
- DECAMETHONIUM BROMIDE
- Synonyms
- decacuran;syncurine;dekamethoniumbromid;DECAMETHONIUM BROMIDE;decamethoniumdibromide;Decamethonium Bromide >Decamethonium bromide ,98%;Decamethonium Bromide, ≥ 98.0%;DECAMETHONIUM BROMIDE USP/EP/BP;DECANE-1,10-BIS(TRIMETHYLAMMONIUM BROMIDE)
- CBNumber:
- CB6360047
- Molecular Formula:
- C16H38Br2N2
- Molecular Weight:
- 418.29
- MDL Number:
- MFCD00011779
- MOL File:
- 541-22-0.mol
- MSDS File:
- SDS
| Melting point | 263-267 °C(lit.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml |
| form | crystalline |
| color | off-white |
| Water Solubility | almost transparency |
| λmax |
λ: 240 nm Amax: 0.04 λ: 250 nm Amax: 0.03 λ: 260 nm Amax: 0.02 λ: 500 nm Amax: 0.02 |
| Merck | 14,2847 |
| BRN | 3728288 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 541-22-0(CAS DataBase Reference) |
| FDA UNII | 55C6RK944K |
| EPA Substance Registry System | Decamethonium dibromide (541-22-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BP5950000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 2923.90.0100 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 oral in mouse: 190mg/kg | |||||||||
| NFPA 704 |
|
DECAMETHONIUM BROMIDE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D1260 | Decamethonium bromide crystalline | 541-22-0 | 5g | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | D1260 | Decamethonium bromide crystalline | 541-22-0 | 10g | $239 | 2024-03-01 | Buy |
| TCI Chemical | D1314 | Decamethonium Bromide >98.0%(T) | 541-22-0 | 5g | $66 | 2024-03-01 | Buy |
| TCI Chemical | D1314 | Decamethonium Bromide >98.0%(T) | 541-22-0 | 25g | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 24907 | Decamethonium (bromide) ≥98% | 541-22-0 | 1g | $32 | 2024-03-01 | Buy |
DECAMETHONIUM BROMIDE Chemical Properties,Uses,Production
Description
Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.
Chemical Properties
crystalline solid
Uses
antipsychotic
brand name
Syncurine (GlaxoSmithKline).
Biological Functions
Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.
General Description
Crystals derived from methanol and acetone.
Air & Water Reactions
Water soluble.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.
Fire Hazard
Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.
DECAMETHONIUM BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27894 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Supplier | Advantage |
|---|---|
| career henan chemical co | 58 |
| TargetMol Chemicals Inc. | 58 |
| Dideu Industries Group Limited | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
| InvivoChem | 58 |
| GIHI CHEMICALS CO.,LIMITED | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| Mainchem Co., Ltd. | 55 |
| J & K SCIENTIFIC LTD. | 76 |
View Lastest Price from DECAMETHONIUM BROMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-08 | DECAMETHONIUM BROMIDE USP/EP/BP
541-22-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-10 | DECAMETHONIUM BROMIDE
541-22-0
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- DECAMETHONIUM BROMIDE USP/EP/BP
541-22-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- DECAMETHONIUM BROMIDE
541-22-0
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co