7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
- CAS No.
- 213743-31-8
- Chemical Name:
- 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
- Synonyms
- RK-24466;KIN001-051;KIN 001-51;d]pyrimidin-4-ylamine;RK-24466 ;RK 24466 ;RK24466;7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR;Lck Inhibitor - CAS 213743-31-8 - Calbiochem;RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466;7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
- CBNumber:
- CB6497372
- Molecular Formula:
- C23H22N4O
- Molecular Weight:
- 370.45
- MDL Number:
- MFCD04974490
- MOL File:
- 213743-31-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8863 | 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3?d]pyrimidin-4-ylamine ≥98% (HPLC) | 213743-31-8 | 5mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 15135 | LCK Inhibitor ≥95% | 213743-31-8 | 500 μg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 15135 | Lck Inhibitor ≥95% | 213743-31-8 | 1mg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 15135 | Lck Inhibitor ≥95% | 213743-31-8 | 5mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 15135 | LCK Inhibitor ≥95% | 213743-31-8 | 10mg | $346 | 2024-03-01 | Buy |
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Chemical Properties,Uses,Production
Uses
Lck Inhibitor is a cell-permeable ATP-competitive inhibitor of Lck.
Definition
ChEBI: RK-24466 is a member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively). It has a role as a geroprotector and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a primary amino compound, a pyrrolopyrimidine, an aromatic amine, an aromatic ether and a member of cyclopentanes.
General Description
A cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (IC50 at 5 μM ATP = <1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck64-509 Y394, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC50 at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC50 = 3.2 μM, >33 μM, >50 μM and >50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50<1-40 nM in Jurkat T cells) and in vivo (ED50 = 4 mg/kg in mice, ip.)
Biochem/physiol Actions
Primary TargetLck?????? Y3
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |