5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
- CAS No.
- 148892-91-5
- Chemical Name:
- 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
- Synonyms
- UQABYHGXWYXDTK-QXQKWMGSSA-N;Guanosine 5′-[β,γ-imido]triphosphate;5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;Guanylyl Imidodiphosphate (trisodium);5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;Guanylyl Imidodiphosphate Trisodium Salt;β:γ-imidoguanosine 5'-triphosphate trisodium salt;GUANOSINE-5-[(B GAMMA)-IMIDO]TRIPHOSPHATE SODIU...;guanosine 5'-[β,γ-imido]triphosphate trisodium salt;5′-Guanylyl-imidodiphosphate trisodium salt hydrate
- CBNumber:
- CB6497387
- Molecular Formula:
- C10H18N6NaO13P3
- Molecular Weight:
- 546.19
- MDL Number:
- MFCD00084770
- MOL File:
- 148892-91-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36/37 |
WGK Germany | 3 |
F | 10-21 |
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | G0635 | Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate ≥85% (HPLC), powder | 148892-91-5 | 5mg | $178 | 2024-03-01 | Buy |
Sigma-Aldrich | G0635 | Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate ≥85% (HPLC), powder | 148892-91-5 | 25mg | $624 | 2024-03-01 | Buy |
Cayman Chemical | 16880 | Guanylyl Imidodiphosphate ≥95% | 148892-91-5 | 1mg | $35 | 2021-12-16 | Buy |
Cayman Chemical | 16880 | Guanylyl Imidodiphosphate ≥95% | 148892-91-5 | 5mg | $105 | 2021-12-16 | Buy |
Sigma-Aldrich | G0635 | Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate ≥85% (HPLC), powder | 148892-91-5 | 100mg | $2000 | 2024-03-01 | Buy |
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Chemical Properties,Uses,Production
Uses
Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.
Uses
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
General Description
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Biochem/physiol Actions
Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Suppliers
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BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
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