METHDILAZINE (200 MG)
- CAS No.
- 1982-37-2
- Chemical Name:
- METHDILAZINE (200 MG)
- Synonyms
- C07175;Tacryl;MJ 5022;Dilosyn;Tacaryl;Tacazyl;Disyncran;Disyncram;NCI-C60720;methdilazine
- CBNumber:
- CB6501372
- Molecular Formula:
- C18H20N2S
- Molecular Weight:
- 296.43
- MDL Number:
- MFCD00242895
- MOL File:
- 1982-37-2.mol
| Melting point | 87-88℃ |
|---|---|
| Boiling point | 170 °C(Press: 0.04 Torr) |
| Density | 1.185 |
| refractive index | 1.6000 (estimate) |
| pka | pKa 7.45 (Uncertain) |
| FDA UNII | 4Q13LY9Z8X |
| ATC code | R06AD04 |
| EPA Substance Registry System | Methdilazine (1982-37-2) |
METHDILAZINE (200 MG) Chemical Properties,Uses,Production
Originator
Tacaryl ,Westwood,US,1960
Uses
Antipruritic.
Definition
ChEBI: Methdilazine is a phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. It has a role as a histamine antagonist, a cholinergic antagonist and an antipruritic drug. It is a member of phenothiazines and a N-alkylpyrrolidine.
Manufacturing Process
10.8 parts of 10-(1-methyl-3-pyrrolidylmethyl) phenothiazine (prepared from 1-methyl-3-pyrrolidylmethyl chloride by reaction with phenothiazine) in 80 parts of 99% isopropyl alcohol were treated with a solution of 1.33 parts of hydrogen chloride in 30 parts of the same solvent. The clear light yellow solution soon deposited white crystals of the acid addition salt. After cooling overnight at 0°C, the crystalline product was collected on a filter, washed with 99% isopropyl alcohol and anhydrous ether and then dried in a vacuum oven at 95°C. Yield 10.4 parts, MP 187.5° to 189°C.
brand name
Tacaryl (Westwood-Squibb).
Therapeutic Function
Antipruritic
General Description
Methdilazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine (Tacaryl), is a light-tan crystallinepowder that has a characteristic odor and is practicallyinsoluble in water. Methdilazine, as the free base, isused in chewable tablets because its low solubility in watercontributes to its tastelessness. Some local anesthesia of thebuccal mucosa may be experienced if the tablet is chewedand not swallowed promptly.
General Description
Crystals.
Reactivity Profile
METHDILAZINE (200 MG) is sensitive to light. .
Health Hazard
SYMPTOMS: Symptoms of exposure to METHDILAZINE (200 MG) may include drowsiness, hypotension, tachycardia, dryness of the mouth, nausea, nasal congestion, fever and tremors.
Fire Hazard
Flash point data for METHDILAZINE (200 MG) are not available. METHDILAZINE (200 MG) is probably combustible.
METHDILAZINE (200 MG) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18810 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | 1027@dideu.com | China | 9902 | 58 |