Phenothiazine
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Phenothiazine Properties
- Melting point:
- 184 °C
- Boiling point:
- 371 °C(lit.)
- Density
- 1.362
- refractive index
- 1.6353
- Flash point:
- 202°C
- storage temp.
- Store below +30°C.
- solubility
- 0.127mg/l
- form
- Prills or Beads
- pka
- pKa 2.52 (Uncertain)
- color
- Yellow
- PH
- 6 (10g/l, H2O, 20℃)(aqueous suspension)
- Water Solubility
- 2 mg/L (25 ºC)
- Sensitive
- Light Sensitive
- Merck
- 14,7252
- BRN
- 143237
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
- InChIKey
- WJFKNYWRSNBZNX-UHFFFAOYSA-N
- CAS DataBase Reference
- 92-84-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Phenothiazine(92-84-2)
- EPA Substance Registry System
- 10H-Phenothiazine(92-84-2)
SAFETY
- Risk and Safety Statements
- Hazard and Precautionary Statements (GHS)
| Hazard Codes | Xi,N,Xn | ||
|---|---|---|---|
| Risk Statements | 36/37/38-43-51/53-36/38-40-20/21/22-52/53-48/22-22 | ||
| Safety Statements | 26-36-61-36/37/39-29-22-36/37 | ||
| WGK Germany | 1 |
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| RTECS | SN5075000 |
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| F | 8-23 | ||
| TSCA | Yes | ||
| HS Code | 29343090 | ||
| Hazardous Substances Data | 92-84-2(Hazardous Substances Data) |
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||||||||||||||||
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Phenothiazine price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 88580 | Phenothiazine purum, ≥98.0% (GC) | 92-84-2 | 1kg | $81.9 | 2018-11-13 | Buy |
| Sigma-Aldrich | 1525707 | Phenothiazine United States Pharmacopeia (USP) Reference Standard | 92-84-2 | 500mg | $348 | 2018-11-13 | Buy |
| TCI Chemical | P0106 | Phenothiazine >98.0%(GC) | 92-84-2 | 25g | $16 | 2018-11-22 | Buy |
| TCI Chemical | P0106 | Phenothiazine >98.0%(GC) | 92-84-2 | 500g | $32 | 2018-11-22 | Buy |
| Alfa Aesar | A12517 | Phenothiazine, 98+% | 92-84-2 | 500g | $35.3 | 2018-11-13 | Buy |
Phenothiazine Chemical Properties,Uses,Production
description
Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors.Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. Phenothiazines may also be used for other conditions as determined by your doctor.
Chemical Properties
It is clean gray-green powder with the melting point of 185.5 ℃, boiling point of 371 ℃, 290 ℃ (5.33kPa). It is insoluble in petroleum ether, chloroform and water, and soluble in ether and hot acetic acid. It will be oxidized upon exposure to light in the air.side effects
For more than a decade, phenothiazine drugs have been used to treat a variety of disorders and have proved particularly effective in the treatment of schizophrenia. Clinical experience indicates that initial extremely high dosages are necessary to effect improvement of patients with schizophrenic illnesses.During 1964, several sequelae have been reported following prolonged high dosage of these drugs. These recent reports refer to side effects which are apparently permanent, in contrast to earlier communications of transient deleterious effects. For example, it has been known for several years that extrapyramidal disorders occur frequently in patients taking phenothiazines; however, a reduction in dosage or cessation of medication appeared to produce a return to the normal state.
Phenothiazines may cause unwanted, unattractive, and uncontrolled face or body movements that may not go away when you stop taking the medicine. They may also cause other serious unwanted effects. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Also, your doctor should look for early signs of these effects at regular visits. Your doctor may be able to stop or decrease some unwanted effects, if they do occur, by changing your dose or by making other changes in your treatment.
These medicines are available only with your doctor's prescription.
Levoprome(R) (methotrimeprazine) is no longer available in the United States. At the end of May 1998, Immunex Corporation stopped marketing it.
Once a medicine has been approved for marketing for a certain use, experience may show that it also is useful for other medical problems. Although these uses are not included in product labeling, phenothiazines are used in certain patients with the following medical conditions:
- Chronic neurogenic pain (certain continuing pain conditions)
- Huntington's chorea (hereditary movement disorder)
- Migraine headaches
Uses
- Phenothiazine is a relatively widely used anthelmintic reagent with excellent efficacy in treating the Haemonchus contortus of cattle, horse and sheep, nodular worm, Bunostomum and Plasmodium chabaudi.
- Phenothiazine is the intermediates of fine chemicals such as dyes and drugs with itself being a auxiliary material for synthetic material (the anti-polymerization reagent for production of vinylon), fruit pesticides and veterinary anthelmintic.
- It is mainly used as the polymerization inhibitor for acrylic acid, acrylic esters, and methacrylic aicd as well as ester monomer.
Synthesis
22 g of diphenylamine, 8.2 g of sulfur, and 3.2 gms. of anhydrous aluminum chloride are melted together. The reaction sets 140-150° C with the rapid evolution of hydrogen sulfide; by lowerg the temperature, a few degrees the reaction can be slackened. Wen the reaction has moderated, the temperature is raised to 160° C for a time. The melt, when cool, is ground up and extracted, first with water and then with dilute alcohol. The residue consists of almost pure phenothiazine. It can be recrystallised from alcohol. Yield 93%, yellowish leaflets; m.p. 180° C.
Systematic organic chemistry, by W. M. Cumming, 325-326, 1937.
Chemical Properties
yellow or pale green powderUses
A key component of antipsychotic and antihistaminic drugs.Uses
Employed in the preparation of carbazoles and piperazines,1 and charge-transfer semiconducting complexes.2Uses
A rigid, tricyclic thiazine useful as an electron donor.Uses
Insecticide; manufacture of pharmaceuticals.Definition
ChEBI: The 10H-tautomer of phenothiazine.brand name
Nemazine (Parke-Davis).General Description
Light green to steel-blue powder. Acquires a greenish-brown tint under exposure to sunlight.Air & Water Reactions
Insoluble in water.Reactivity Profile
Phenothiazine is slowly decomposed by sunlight. . Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.Fire Hazard
Flash point data for Phenothiazine are not available, but Phenothiazine is probably combustible.Purification Methods
Crystallise it from *benzene, toluene, hexane or Me2CO (charcoal) after boiling for 10minutes under reflux. Filter the crystals off and dry them in an oven at 100o, then in a vacuum desiccator over paraffin chips. Also recrystallise it twice from water and dry it in an oven at 100o for 8-10hours. It sublimes at 130o/1mm and has UV with at 253nm in heptane. [BeilsteinPhenothiazine Preparation Products And Raw materials
Raw materials
Preparation Products
SODIUM PHENOTHIAZINE-10-YL-PROPYLSULFONATE
Promethazine hydrochloride
CARBAMIC ACID, [10-[3-(4-MORPHOLINYL)-1-OXOPROPYL]-10H-PHENOTHIAZIN-2-YL]-, ETHYL ESTER
Acrylamide
Phenothiazine Suppliers
Global( 292)Suppliers
| Supplier | Tel | Fax | Country | ProdList | Advantage | |
|---|---|---|---|---|---|---|
| Henan DaKen Chemical CO.,LTD. | +86-371-55531817 |
info@dakenchem.com | CHINA | 22080 | 58 | |
| Henan Tianfu Chemical Co.,Ltd. | 0371-55170693 |
0371-55170693 | info@tianfuchem.com | CHINA | 20795 | 55 |
| Mainchem Co., Ltd. | +86-0592-6210733 |
+86-0592-6210733 | sales@mainchem.com | CHINA | 32764 | 55 |
| PI & PI BIOTECH INC. | 020-81716320 |
020-81716319 | Sales@pipitech.com | CHINA | 2549 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 86-0551-65418684 18949823763 |
86-0551-65418684 | info@tnjchem.com | China | 1523 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3624 | 58 | |
| Shanghai TongYuan Chemical Co., Ltd. | 021-69182866 69186366 |
021-69182022 | tongyuanchem@126.com | China | 5184 | 58 |
| Shanghai LanRun Chemical Co., Ltd. | 021-69515658 ; 69515628 |
021-69515998 | longrunchem@163.com | China | 5966 | 50 |
| Shanghai XiZhi Chemical Co., Ltd. | 021-69005855 |
021-69005955 | xizhichem@163.com | China | 4254 | 55 |
| J & K SCIENTIFIC LTD. | 400-666-7788 +86-10-82848833 |
+86-10-82849933 | jkinfo@jkchemical.com;market6@jkchemical.com | China | 96815 | 76 |
92-84-2(Phenothiazine)Related Search:
2-TRIFLUROMETHYL PHENOTHIAZINE cyano-3((hydroxy-4piperidyl-1)-3propyl)-10phenothiazin PHENOTHIAZINE SOLUTION 100UG/ML IN TOLUENE 1ML 2-Methoxy-10H-phenothiazine,Phenothiazine, 2-methoxy- 2-Acetylphenothiazine 3-methoxy-10H-phenothiazine 3,7-dinitrophenothiazine 5-oxide 2-Chlorophenothiazine PHENOTHIAZINE-5-OXIDE Promethazine hydrochloride 2-(Trifluoromethyl)phenothiazine FLUPHENAZINE N-MUSTARD DIHYDROCHLORIDE 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE Chlorpromazine hydrochloride PERPHENAZINE THIORIDAZINE HYDROCHLORIDE FLUPHENAZINE HYDROCHLORIDE AKOS 93807
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