APHIDICOLIN
- CAS No.
- 38966-21-1
- Chemical Name:
- APHIDICOLIN
- Synonyms
- APC;ici69653;nsc-234714;APHIDICOLIN;(+)-APHIDICOLIN;,11a-beta,11b-beta))-;APHIDICOLIN USP/EP/BP;Aphidicolin, Ready Made Solution;(+)-APHIDICOLIN, NIGROSPORA ORYZAE;Aphidicolin, froM Nigrospora oryzae
- CBNumber:
- CB6683304
- Molecular Formula:
- C20H34O4
- Molecular Weight:
- 338.48
- MDL Number:
- MFCD00083214
- MOL File:
- 38966-21-1.mol
- MSDS File:
- SDS
Melting point | 218-220°C |
---|---|
alpha | D27 +12° (c = 1 in methanol) |
Boiling point | 394.61°C (rough estimate) |
Density | 1.0057 (rough estimate) |
vapor pressure | 0.55 hPa ( 20 °C) |
refractive index | 1.4434 (estimate) |
Flash point | 87℃ |
storage temp. | 2-8°C |
solubility | ethanol: soluble1mg/mL (stable at least a week at 4°C.) |
form | White solid |
pka | 14.24±0.70(Predicted) |
color | colorless |
optical activity | [α]27/D +12°, c = 1 in methanol(lit.) |
Water Solubility | Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20° |
Merck | 13,734 |
BRN | 4689958 |
Stability | Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
FDA UNII | 192TJ6PP19 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P271-P280 | |||||||||
Safety Statements | 22-24 | |||||||||
RIDADR | NA 1993 / PGIII | |||||||||
WGK Germany | 3 | |||||||||
RTECS | PB9185000 | |||||||||
F | 10-21 | |||||||||
HS Code | 29419090 | |||||||||
NFPA 704 |
|
APHIDICOLIN price More Price(27)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 89458 | Aphidicolin analytical standard | 38966-21-1 | 5mg | $1120 | 2024-03-01 | Buy |
Sigma-Aldrich | 5.04744 | InSolution Aphidicolin - CAS 38966-21-1 - Calbiochem | 38966-21-1 | 1mg | $167 | 2024-03-01 | Buy |
Sigma-Aldrich | 178273 | Aphidicolin | 38966-21-1 | 1mg | $144 | 2024-03-01 | Buy |
Alfa Aesar | J60236 | Aphidicolin | 38966-21-1 | 1mg | $207 | 2023-06-20 | Buy |
Alfa Aesar | J60236 | Aphidicolin | 38966-21-1 | 5mg | $607 | 2023-06-20 | Buy |
APHIDICOLIN Chemical Properties,Uses,Production
Description
(+)-
Chemical Properties
White crystal
Uses
A DNA polymerase inhibitor. Blocks the cell cycle at the early S-phase
Uses
Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumour agents, vincristine and doxorubicin.
Uses
(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.
Definition
ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
General Description
A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
Biochem/physiol Actions
Cell permeable: yes
storage
+4°C
References
1) Syvaoja et al. (1990), DNA polymerases alpha, delta, and epsilon: three distinct enzymes from HeLa cells; Proc. Natl. Acad. Sci. USA, 87 6664 2) Urbani et al. (1995), Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization; Exp. Cell Res., 219 159 3) Kuwakado et al. (1993), Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines; Biochem. Pharmacol., 46 1909 4) Yin and Schimke (1996), Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment; Proc. Natl. Acad. Sci. USA, 93 3394
APHIDICOLIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7730 | 58 |
AFINE CHEMICALS LIMITED | +86-008657185134551 +86-18958018566 | sales@afinechem.com | China | 15394 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50003 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
View Lastest Price from APHIDICOLIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-26 | APHIDICOLIN
38966-21-1
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
- APHIDICOLIN
38966-21-1
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co