ChemicalBook >> CAS DataBase List >>1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
- CAS No.
- 84477-87-2
- Chemical Name:
- 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
- Synonyms
- H-7;H-72HCl;H-7 inhibitor;Protein kinase inhibitor H-7;1-(5-Isoquinolylsulfonyl)-2-methylpiperazine;1-(5-isoquinolinesulfonyl)-2-methylpiperazine;Isoquinoline-5-sulfonic 2-methyl-1-piperazide;5-(2-methylpiperazine-1-sulfonyl)isoquinoline;5-(2-methylpiperazin-1-yl)sulfonylisoquinoline;1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
- CBNumber:
- CB6719627
- Molecular Formula:
- C14H17N3O2S
- Molecular Weight:
- 291.37
- MDL Number:
- MFCD00063403
- MOL File:
- 84477-87-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-04-21 10:31:43
| Product description | Number | Pack Size | Price |
| H-7 | I6891 | 25mg | $1060 |
| H-7 | I6891 | 5mg | $324 |
| H-7 95.00% | KIN0000366 | 10MG | $653.68 |
| H-7 95.00% | KIN0000366 | 50MG | $1012.65 |
| 5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline 97% | CM229708 | 1g | $729 |
| Boiling point | 495.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.277±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ethanol: 20 mg/mL |
| form | Solid |
| pka | 7.69±0.40(Predicted) |
| color | White to light yellow |
| BRN | 5482740 |
| FDA UNII | 487H9Q0F9N |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| RTECS | TL9305000 |
| F | 10 |
| Toxicity | LD50 intravenous in mouse: 94mg/kg |
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I6891 | H-7 | 84477-87-2 | 25mg | $1060 | 2024-03-01 | Buy |
| Sigma-Aldrich | I6891 | H-7 | 84477-87-2 | 5mg | $324 | 2023-06-20 | Buy |
| American Custom Chemicals Corporation | KIN0000366 | H-7 95.00% | 84477-87-2 | 10MG | $653.68 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000366 | H-7 95.00% | 84477-87-2 | 50MG | $1012.65 | 2021-12-16 | Buy |
| Chemenu | CM229708 | 5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline 97% | 84477-87-2 | 1g | $729 | 2021-12-16 | Buy |
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Chemical Properties,Uses,Production
Uses
Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].
Definition
ChEBI: A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Biological Activity
Protein kinase inhibitor. IC 50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μ M respectively.
IC 50
PKC: 6 μM (Ki)
References
[1] Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41. DOI:10.1021/bi00316a032
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Suppliers
Global( 56)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53802 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 977 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7999 | 62 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9550 | 58 |
View Lastest Price from 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Protein kinase inhibitor H-7
84477-87-2
|
US $52.00-117.00 / mg | 99.91% | 10g | TargetMol Chemicals Inc. |
-
- Protein kinase inhibitor H-7
84477-87-2
- US $52.00-117.00 / mg
- 99.91%
- TargetMol Chemicals Inc.
84477-87-2(1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE)Related Search:
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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
(S)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE
(R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride
1of2
1-(5-isoquinolinesulfonyl)-2-methylpiperazine
1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
1-(5-isoquinolinylsulfonyl)-2-*methylpiperazine F
1-(5-ISOQUINOLINYLSULFONYL)-2-*METHYLPIP ERAZINE FRE
H-72HCl
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide
(Isoquinoline-5-yl)(2-methylpiperazine-1-yl) sulfone
1-(5-Isoquinolylsulfonyl)-2-methylpiperazine
5-(2-methylpiperazin-1-yl)sulfonylisoquinoline
Isoquinoline-5-sulfonic 2-methyl-1-piperazide
5-[(2-methyl-1-piperazinyl)sulfonyl]Isoquinoline
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
H-7
Isoquinoline, 5-[(2-methyl-1-piperazinyl)sulfonyl]-
Protein kinase inhibitor H-7
H-7 inhibitor
(+/-)-1-(5-Isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride
84477-87-2
Cell Biology
Cell Signaling and Neuroscience
BioChemical
Kinase/Phosphatase Biology
Protein kinase A and protein kinase C (PKA and PKC)
Serine/Threonine Kinase Inhibitors
