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Description References
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

8-Methoxypsoralen Properties

Melting point:
148-150 °C(lit.)
Boiling point:
276.6°C (rough estimate)
1.1344 (rough estimate)
refractive index 
1.4270 (estimate)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
H2O: slightly soluble
Needle-Like Crystals or Powder
white to yellow
Water Solubility 
CAS DataBase Reference
298-81-7(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
7H-Furo[3,2-g][1] benzopyran-7-one, 9-methoxy-(298-81-7)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T
Risk Statements  22-43-46-45-34
Safety Statements  36/37-53-45-36/37/39-26
RIDADR  3216
WGK Germany  3
RTECS  LV1400000
Hazardous Substances Data 298-81-7(Hazardous Substances Data)
Toxicity LD50 i.p. in rats: 470 ±30 mg/kg (Hakim)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.

8-Methoxypsoralen price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 56448 Xanthotoxin analytical standard 298-81-7 50mg $93.7 2018-11-20 Buy
Sigma-Aldrich 1417001 Methoxsalen United States Pharmacopeia (USP) Reference Standard 298-81-7 200mg $352.8 2018-11-20 Buy
TCI Chemical X0009 Xanthotoxin >98.0%(GC) 298-81-7 100mg $12 2018-11-22 Buy
TCI Chemical X0009 Xanthotoxin >98.0%(GC) 298-81-7 1g $43 2018-11-22 Buy
Alfa Aesar A17108 8-Methoxypsoralen, 99% 298-81-7 1g $31 2018-11-13 Buy

8-Methoxypsoralen Chemical Properties,Uses,Production


8-methoxypsoralen (also known as methoxsalen) is a naturally occurring furocoumarin compound existing in several species of plants such as Psoralea corylifolia. It is a photoactive substance that can form DNA adducts upon UVA irradiation. It is a drug used for the treatment of psoriasis, eczema, vitiligo, and some kinds of cutaneous lymphomas associated with the exposure of skin to the UVA or light from lamps or sunlight. Its mechanism of action is through inhibiting the synthesis of the deoxyribonucleic acid (DNA). After the activation, it can preferentially bind to the guanine and cytosine molecules of DNA, further leading to the cross-linking of DNA, thus inhibiting the DNA synthesis. It can further inhibit the RNA and protein synthesis at high concentration. It is extracted from Ammi majus.


Chemical Properties

White to cream-colored, crystalline solid; odorless. Slightly soluble in alcohol; practically insoluble in water. Combustible.


antipsoriatic, pigmentation agent


Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides.


For the treatment of psoriasis and vitiligo


A potent suicide inhibitor of cytochrome P-450.


Naturally occurring analog of psoralen. Use in treatment of psoriasis and mycosis fungoides


ChEBI: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.

brand name

8-Mop (Valeant); Oxsoralen (Valeant); Uvadex (Therakos).

General Description

Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation.

Air & Water Reactions

Sensitive to light and air. Insoluble in water.

Reactivity Profile

8-Methoxypsoralen is incompatible with strong oxidizing agents.

Fire Hazard

Flash point data for 8-Methoxypsoralen are not available; however, 8-Methoxypsoralen is probably combustible.

Contact allergens

This fur(an)ocoumarin is an phototoxic compound that causes phototoxic dermatitis. Many plants of the Apiaceae–Umbelliferae and most of the Rutaceae family contain 5-methoxypsoralen and 8-methoxypsoralen. Their spectra is in the UVA range (300–360 nm). It is used in combination with UVA to treat various skin disorders such as psoriasis.

Safety Profile

Confirmed carcinogen. Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. A drug used to treat slun diseases.

Purification Methods

Purify xanthotoxin by recrystallisation from *C6H6/pet ether (b 60-80o) to give silky needles, or from EtOH/Et2O to give rhombic prisms or from hot H2O to give needles. It is soluble in aqueous alkali due to ring opening of the cyclic lactone but recyclises upon acidification. It has UV max in EtOH at 219, 249 and 300nm (log  4.32, 4.35 and 4.06) and 1H NMR in CDCl3 with at 7.76 (d, 1H, J 10 Hz), 7.71 (d, 1H, J 2.5 Hz), 7.38 (s, 1H), 6.84 (d, 1H, J 2.5 Hz), 6.39 (d, 1H, J 10 Hz) and 4.28 (s, 3H)ppm. [Nore & Honkanen J Heterocycl Chem 17 985 1980.] It is a DNA intercalator, is used in the treatment of dermal diseases, and is a human carcinogen [Tessman et al. Biochemistry 24 1669 1985.] [Beilstein 19 I 711, 19/6 V 15.]

8-Methoxypsoralen Preparation Products And Raw materials

Raw materials

Preparation Products

8-Methoxypsoralen Suppliers

Global( 249)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19958 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32763 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2200 58
Kono Chem Co., Ltd
+86-132 8924 6953 CHINA 2164 58
Chengdu GLP Biotech Co., Ltd
13350802083 CHINA 1002 58
career henan chemical co
+86-371-86658258 CHINA 20000 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3624 58
Changzhou Pumelo Co.,Ltd. 0519-81698808
0519-81698098 China 89 55

View Lastest Price from 8-Methoxypsoralen manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 8-Methoxypsoralen
US $1.00 / KG 1G 98% 100KG career henan chemical co

8-Methoxypsoralen Spectrum

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