Psoralen
- CAS No.
- 66-97-7
- Chemical Name:
- Psoralen
- Synonyms
- FICUSIN;Furocoumarin;Psoralene;Psoralea extract;7H-Furo[3,2-g]chromen-7-one;7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE;PSORALEN;Prosuler;Psorline-P;NSC 404562
- CBNumber:
- CB3181900
- Molecular Formula:
- C11H6O3
- Molecular Weight:
- 186.16
- MDL Number:
- MFCD00010520
- MOL File:
- 66-97-7.mol
- MSDS File:
- SDS
| Melting point | 160-162 °C |
|---|---|
| Boiling point | 280.64°C (rough estimate) |
| Density | 1.2477 (rough estimate) |
| refractive index | 1.6310 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| color | White to Off-White |
| Water Solubility | 65.16mg/L(25 ºC) |
| λmax | 328nm(EtOH)(lit.) |
| Merck | 14,7928 |
| BRN | 152784 |
| InChIKey | ZCCUUQDIBDJBTK-UHFFFAOYSA-N |
| LogP | 1.670 |
| CAS DataBase Reference | 66-97-7(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | psoralen |
| FDA UNII | KTZ7ZCN2EX |
| NIST Chemistry Reference | 7H-furo[3,2-g][1]benzopyran-7-one(66-97-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LV0944000 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Psoralen price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P8399 | Psoralen ≥99% (HPLC) | 66-97-7 | 10mg | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | 73633 | Psoralen analytical standard | 66-97-7 | 10mg | $508 | 2022-05-15 | Buy |
| TCI Chemical | P2077 | Psoralen >99.0%(GC) | 66-97-7 | 20mg | $70 | 2024-03-01 | Buy |
| TCI Chemical | P2077 | Psoralen >99.0%(GC) | 66-97-7 | 100mg | $209 | 2024-03-01 | Buy |
| Alfa Aesar | J60042 | Psoralen, 97% | 66-97-7 | 100mg | $241.65 | 2024-03-01 | Buy |
Psoralen Chemical Properties,Uses,Production
Description
Psoralen is a kind of naturally occurring furocoumarin. It is naturally occurred in the seeds of Psoralea corylifolia as well as in the common fig, celery, parsley, West Indian Satinwood and all citrus fruits. It is capable of binding to DNA via single- and double-strand cross-linking upon photoactivation with UV radiation. It can intercalate with DNA, blocking its synthesis and cell division. For this reason, it is an important mutagen and can be used in related molecular biology studies. It also exhibits anti- proliferative, anti-allergenic and anti-histamine functions. It can also be used in PUVA treatment for skin diseases such as psoriasis, eczema and vitiligo. It is also effective tanning activator in sunscreens. Some of its derivatives, e.g. amino-psoralen, amotosalen HCl, can even inactivate pathogens in blood products.
References
https://en.wikipedia.org/wiki/Psoralen
https://pubchem.ncbi.nlm.nih.gov/compound/Psoralen#section=Top
Chemical Properties
Crystalline Solid
Uses
Use as photochemical probe in biological systems
Uses
Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.
Uses
As photochemical probe in biological systems: P.-S. Song, C.-N. Ou, Ann. N.Y. Acad. Sci. 346, 355 (1980).
Definition
ChEBI: The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 6735, 1984 DOI: 10.1021/ja00334a044
Synthetic Communications, 37, p. 63, 2007 DOI: 10.1080/00397910600978093
Biochem/physiol Actions
Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis
Psoralen Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 290 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
View Lastest Price from Psoralen manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Psoralen
66-97-7
|
US $0.00-0.00 / kg | 0.10000000149011612kg | ≥98% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2024-04-22 | Psoralen
66-97-7
|
US $0.00 / kg | 1kg | 99.8% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2024-04-17 | Psoralen
66-97-7
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd |