Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]-
![Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Structure](CAS/20210305/GIF/2782024-58-0.gif)
- CAS No.
- 2782024-58-0
- Chemical Name:
- Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]-
- Synonyms
- Phenyl-glutarimide 4'-oxyacetic acid;2-[4-(2,6-Dioxo-3-piperidyl)phenoxy]acetic Acid;2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid;Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]-
- CBNumber:
- CB712059765
- Molecular Formula:
- C13H13NO5
- Molecular Weight:
- 263.25
- MDL Number:
- MOL File:
- 2782024-58-0.mol
Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Chemical Properties,Uses,Production
Uses
Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy[1].
Biological Activity
Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC? Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs
IC 50
Cereblon
storage
Store at -20°C
References
[1] Min J, et al. Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew Chem Int Ed Engl. 2021 Dec 13;60(51):26663-26670. DOI:10.1002/anie.202108848
Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
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| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 | sales@pharmablock.com | China | 7268 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-025-66113011 18626450290 | cb5@aikonchem.com | China | 10358 | 58 |
| Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd | 13005928603 | 211017228@qq.com | China | 8276 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 31870 | 58 |
