ETHYL 3-(N-METHYLAMINO) PROPIONATE
- CAS No.
- 2213-08-3
- Chemical Name:
- ETHYL 3-(N-METHYLAMINO) PROPIONATE
- Synonyms
- 114537;Ethyl N-Methyl-β-alaninate;Ethyl N-methyl-beta-alaninate;N-Methyl-b-alanine ethyl ester;Ethyl 3-(MethylaMino)propanoate;ethyl N-methyl-2-aminopropionate;β-Alanine, N-methyl-, ethyl ester;ETHYL 3-(N-METHYLAMINO) PROPIONATE;.beta.-Alanine, N-methyl-, ethyl ester;3-methylaminopropionic acid ethyl ester
- CBNumber:
- CB7128338
- Molecular Formula:
- C6H13NO2
- Molecular Weight:
- 131.18
- MDL Number:
- MFCD00672194
- MOL File:
- 2213-08-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| EthylN-Methyl-β-alaninate | E923360 | 1g | $120 |
| Ethyl N-Methyl-beta-alaninate | 449697 | 1g | $425 |
| EthylN-Methyl-β-alaninate | E923360 | 25g | $2135 |
| ETHYL 3-(METHYLAMINO)PROPANOATE 95.00% | CHM0122031 | 5G | $1759.28 |
| EthylN-methyl-beta-alaninate | 7579AD | 1g | $112 |
| More product size | |||
| Boiling point | 242.49°C (rough estimate) |
|---|---|
| Density | 1.0070 |
| refractive index | 1.4443 (estimate) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 9.55±0.10(Predicted) |
| color | Colourless |
| InChI | InChI=1S/C6H13NO2/c1-3-9-6(8)4-5-7-2/h7H,3-5H2,1-2H3 |
| InChIKey | XVIJMHJTEHBUJI-UHFFFAOYSA-N |
| SMILES | C(=O)(OCC)CCNC |
SAFETY
Risk and Safety Statements
| Risk Statements | 36/37/38 |
|---|---|
| Safety Statements | 26-36/37/39 |
| HS Code | 2922498590 |
ETHYL 3-(N-METHYLAMINO) PROPIONATE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E923360 | EthylN-Methyl-β-alaninate | 2213-08-3 | 1g | $120 | 2021-12-16 | Buy |
| Usbiological | 449697 | Ethyl N-Methyl-beta-alaninate | 2213-08-3 | 1g | $425 | 2021-12-16 | Buy |
| TRC | E923360 | EthylN-Methyl-β-alaninate | 2213-08-3 | 25g | $2135 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0122031 | ETHYL 3-(METHYLAMINO)PROPANOATE 95.00% | 2213-08-3 | 5G | $1759.28 | 2021-12-16 | Buy |
| AK Scientific | 7579AD | EthylN-methyl-beta-alaninate | 2213-08-3 | 1g | $112 | 2021-12-16 | Buy |
ETHYL 3-(N-METHYLAMINO) PROPIONATE Chemical Properties,Uses,Production
Uses
Ethyl N-Methyl-beta-alaninate is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 2124, 1949 DOI: 10.1021/ja01174a061
Synthesis
74-89-5
140-88-5
2213-08-3
1. cool 33% methylamine ethanol solution (100 mL, 805 mmol) in an ice bath at 0 °C. 2. Ethyl acrylate (11.0 mL, 10.1 g, 101 mmol) was added slowly, keeping the reaction temperature at 0 °C with continuous stirring for 2 hours. 3. Gradually warm the reaction mixture to room temperature and continue stirring for 15 minutes. 4. All volatiles were removed by distillation under reduced pressure. 5. The resulting residue (ethyl 3-(methylamino)propionate crude, 11.2 g) was used directly in the subsequent reaction without further purification.
References
[1] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1055 - 1059
[2] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980, p. 1739 - 1745
[3] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 1, p. 87 - 91
[4] Liebigs Annalen der Chemie, 1980, # 9, p. 1438 - 1447
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 2129
ETHYL 3-(N-METHYLAMINO) PROPIONATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1984 | 58 |
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