Altrenogest
- CAS No.
- 850-52-2
- Chemical Name:
- Altrenogest
- Synonyms
- 11-trien-3-one,17-alpha-allyl-17-hydroxy-estra-9;Estra-4,9,11-trien-3-one, 17-hydroxy-17-(2-propenyl)-, (17b)-;r2267;D02840;ru2267;A 35957;drc6246;REGUMATE;ltrenogest;Altrenoges
- CBNumber:
- CB7211951
- Molecular Formula:
- C21H26O2
- Molecular Weight:
- 310.44
- MDL Number:
- MFCD00867855
- MOL File:
- 850-52-2.mol
- MSDS File:
- SDS
| Melting point | 120° |
|---|---|
| alpha | D20 -72° (c = 0.5 in ethanol) |
| Boiling point | 390.58°C (rough estimate) |
| Density | 1.0865 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml |
| pka | 14.59±0.40(Predicted) |
| color | White to Yellow |
| Merck | 14,319 |
| InChI | InChI=1/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/s3 |
| InChIKey | VWAUPFMBXBWEQY-ANULTFPQSA-N |
| SMILES | C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)CC=C |&1:1,14,16,20,r| |
| FDA 21 CFR | 556.36 |
| FDA UNII | 2U0X0JA2NB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H360FD-H373-H410 | |||||||||
| Precautionary statements | P202-P260-P264-P270-P273-P301+P310 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KG7745000 | |||||||||
| HS Code | 2937.23.5050 | |||||||||
| NFPA 704 |
|
Altrenogest price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 33994 | Altrenogest VETRANAL?, analytical standard | 850-52-2 | 100MG | $119 | 2024-03-01 | Buy |
| TCI Chemical | A2892 | Altrenogest >98.0%(HPLC) | 850-52-2 | 200mg | $63 | 2024-03-01 | Buy |
| TCI Chemical | A2892 | Altrenogest >98.0%(HPLC) | 850-52-2 | 1g | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 27218 | Altrenogest | 850-52-2 | 250mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 27218 | Altrenogest | 850-52-2 | 500mg | $116 | 2024-03-01 | Buy |
Altrenogest Chemical Properties,Uses,Production
Description
Altrenogest is used to suppress estrus in mares in order to facilitate induction of normal estrous cycle activity. It is also used in mares to synchronize scheduled breeding activity. In the suppression of estrous behavior in mares, this is usually related to mares that are used as performance horses.
Application
Altrenogest is a progestin of the 19-nortestosterone group. As a veterinary medication, it is used extensively in the reproductive management of mares to control the reproductive cycle, help maintain pregnancy, and help with behavior modification. Altrenogest has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares that abort due to subtherapeutic progestin levels. Altrenogest is typically administered orally by applying directly on the base of the mare’s tongue or on the mare’s feed.
Uses
Altrenogest is used for suppression of estrus. The mare will experience a predictable occurrence of estrus following drug withdrawal. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. By managing the reproductive cycle, horse owners have more control over breeding procedures and the timing of the arrival of foals.
Biological Activity
Altrenogest suspension by NexGen is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus, and permitting scheduled breeding. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced.
Interactions
Rifampin may increase the speed of metabolism of Regu-Mate.
in vitro
Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone. Treatment of embryo-recipient mares with Altrenogest (Allyltrenbolone) appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer. The oil and gel Altrenogest (Allyltrenbolone) preparations are equally effective in modulating estrous behavior and time to estrus and ovulation. Altrenogest (Allyltrenbolone) treatment started late in diestrus appears to result in a high incidence of ovulation during treatment and when luteolysis and ovulation occur during treatment; the subsequent luteal phase is frequently prolonged due to failure of regression of the CL.
Chemical Properties
Pale Yellow Solid
Uses
Altrenogest can be used as a synthetic progestational agent used in veterinary medicine for the control of estrus in mares and antineoplastic.
Definition
ChEBI: Altrenogest is a 3-hydroxy steroid.
brand name
REGUMATE (Roussel-UCLAF, France).
Side effects
People exposed to altrenogest products have potential health risks. Reproductive adverse effects reported in women and girls include abnormal or absent menstrual cycles, and in men include decreased libido. Other adverse effects reported after exposure include headaches, fever, abdominal pain, nausea, diarrhea, vomiting, and rashes.
Altrenogest causes essentially no side effects in mares, and it may be used for prolonged periods.
Veterinary Drugs and Treatments
Altrenogest (Regu-Mate) is indicated (labeled) to suppress estrus
in mares to allow a more predictable occurrence of estrus following
withdrawal of the drug. It is used clinically to assist mares to establish
normal cycles during the transitional period from anestrus
to the normal breeding season often in conjunction with an artificial
photoperiod. It is more effective in assisting in pregnancy attainment
later in the transition period. Some authors (Squires et
al. 1983) suggest selecting mares with considerable follicular activity
(mares with one or more follicles 20 mm or greater in size) for
treatment during the transitional phase. Mares that have been in
estrus for 10 days or more and have active ovaries are also considered
excellent candidates for progestin treatment.
Altrenogest is effective in normally cycling mares for minimizing
the necessity for estrus detection, for the synchronization of estrus,
and permitting scheduled breeding. Estrus will ensue 2 – 5 days after
treatment is completed and most mares ovulate between 8 – 15
days after withdrawal. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced. Although the
drug is labeled as contraindicated during pregnancy, it has been
demonstrated to maintain pregnancy in oophorectomized mares
and may be of benefit in mares that abort due to sub-therapeutic
progestin
levels.
The product Matrix is labeled for synchronization of estrus
in sexually mature gilts that have had at least one estrous cycle.
Treatment with altrenogest results in estrus (standing heat) 4-9 days
after completion of the 14-day treatment period.
Altrenogest has been used in dogs for luteal insufficiency and as a
treatment to prevent premature delivery.
Altrenogest Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Bonster Technology Co.,Limited | +8613315996897 | bsterltd.wendy@gmail.com | China | 796 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2118 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | ada@sh-teruiop.com | China | 893 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
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View Lastest Price from Altrenogest manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Altrenogest
850-52-2
|
US $11.00-90.00 / kg | 0.10000000149011612kg | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-25 | Altrenogest
850-52-2
|
US $100.00 / kg | 1kg | 99.9% | 20tons | Hong Kong Excellence Biotechnology Co., Ltd. | |
 |
2024-04-22 | Altrenogest
850-52-2
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Altrenogest
850-52-2
- US $11.00-90.00 / kg
- 99%
- Hebei Kangcang new material Technology Co., LTD
-
- Altrenogest
850-52-2
- US $100.00 / kg
- 99.9%
- Hong Kong Excellence Biotechnology Co., Ltd.
-
- Altrenogest
850-52-2
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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