Salicylazosulfapyridine Chemical Properties,Uses,Production
Brand Name(s)
Azulfidine (Salazopyrin in Canada)
Chemical Properties
Brownish-Yellow Crystals
Uses
Anti-inflammatory (gastrointestinal). Has been used in granulomatous colitis.
Uses
anticolitis and Crohn's disease
Uses
Sulfasalazine is an anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.
Uses
An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer
Definition
ChEBI: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Uses
Sulfasalazine is a prodrug of the anti-inflammatory agent 5-aminosalicylic acid that is covalently linked to the antibiotic sulfapyridine by an azo bond. This bond is rapidly cleaved by bacteria in the terminal ileum and colon, thus releasing the active anti-inflammatory component. It has long been used in treatment of inflammatory bowel disease and rheumatoid arthritis because of its ability to induce T lymphocyte apoptosis, modulate inflammatory mediators from both cyclooxygenase/5-lipoxygenase pathways and NF-κB signaling pathways, attenuate transcription of proinflammatory cytokines, and activate PPARγ.[Cayman Chemical]
General Description
Odorless yellow or brownish-yellow to orange powder. Tasteless.
Air & Water Reactions
Light sensitive and may be sensitive to prolonged exposure to air. Dust can be explosive when suspended in air at specific concentrations. Insoluble in water.
Fire Hazard
Flash point data for Salicylazosulfapyridine are not available; however, Salicylazosulfapyridine is probably combustible.
Salicylazosulfapyridine Preparation Products And Raw materials
