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WORTMANNIN

WORTMANNIN
WORTMANNIN
CAS No.
19545-26-7
Chemical Name:
WORTMANNIN
Synonyms
KY 1242;sl-2052;KY 12420;WORTMANNIN;Wortmammin;Wortmannin,98%;WORTMANNINTOXIN;antibioticsl-2052;Wortmannin solution;Wortmannin,KY 12420
CBNumber:
CB7241293
Molecular Formula:
C23H24O8
Formula Weight:
428.43
MOL File:
19545-26-7.mol

WORTMANNIN Properties

Melting point:
234-240 °C
Boiling point:
463.31°C (rough estimate)
alpha 
+80.0~+105.0゜(20℃/D)(c=0.1,C2H5OH)
Density 
1.2454 (rough estimate)
refractive index 
1.4480 (estimate)
Flash point:
2℃
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
powder
color 
off-white
Sensitive 
Light Sensitive
λmax
296nm(lit.)
Merck 
14,10053
BRN 
67676
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+,T,Xi,Xn,F
Risk Statements  26/27/28-36/37/38-36-20/21/22-11
Safety Statements  28-36/37-45-37/39-26-16
RIDADR  UN 3462 6.1/PG 1
WGK Germany  3
RTECS  CB9641000
3-8-10
HazardClass  6.1
PackingGroup  I
HS Code  29322090
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P302+P350 IF ON SKIN: Gently wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

WORTMANNIN price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 681675 Wortmannin 19545-26-7 1mg $86 2018-11-20 Buy
Sigma-Aldrich W1628 Wortmannin from 19545-26-7 1mg $89.1 2018-11-20 Buy
TCI Chemical W0007 Wortmannin >98.0%(HPLC) 19545-26-7 20mg $236 2018-11-22 Buy
Alfa Aesar J63983 Wortmannin, Penicillium funiculosum, 99+% 19545-26-7 25mg $245 2018-11-13 Buy
Alfa Aesar J63983 Wortmannin, Penicillium funiculosum, 99+% 19545-26-7 10mg $113 2018-11-13 Buy

WORTMANNIN Chemical Properties,Uses,Production

Chemical Properties

White to pale yellow powder

Uses

Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumour and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo.

Uses

Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumor and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo.

Biological Activity

Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC 50 = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC 50 = 5.8 nM).

WORTMANNIN Preparation Products And Raw materials

Raw materials

Preparation Products


WORTMANNIN Suppliers

Global( 102)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19990 58
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4150 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 400-900-4166
1514189587@qq.com China 52642 58
Shanghai Lollane Biological Technology Co.,Ltd. +86-21-52996696
+86-21-52996696 sales@lollanechem.com China 1834 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40395 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24648 81
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 280 60
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21889 59

View Lastest Price from WORTMANNIN manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 WORTMANNIN
19545-26-7
US $2.00 / kg 1kg 99% 100kg career henan chemical co

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