5-Dehydro Tolvaptan
- CAS No.
- 137973-76-3
- Chemical Name:
- 5-Dehydro Tolvaptan
- Synonyms
- Dehydrotolvaptan;5-Dehydro Tolvaptan;Tolvaptan Intermediate;Tolvaptan 5-Oxo Analog;Tolvaptan impurity 5 (DM-21826);7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-ox...;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methy;N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbe;7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
- CBNumber:
- CB72500620
- Molecular Formula:
- C26H23ClN2O3
- Molecular Weight:
- 446.93
- MDL Number:
- MFCD19440797
- MOL File:
- 137973-76-3.mol
- MSDS File:
- SDS
Melting point | >118°C (dec.) |
---|---|
Boiling point | 593.2±50.0 °C(Predicted) |
Density | 1.307 |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 12.97±0.70(Predicted) |
color | White to Off-White |
InChIKey | VENGMROMZOKURN-UHFFFAOYSA-N |
SMILES | C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(=O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C |
FDA UNII | YR22W5RA83 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H413 |
Precautionary statements | P501-P273-P270-P264-P301+P312+P330 |
5-Dehydro Tolvaptan price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | D230350 | 5-DehydroTolvaptan | 137973-76-3 | 50mg | $1190 | 2021-12-16 | Buy |
Matrix Scientific | 096805 | N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 95+% | 137973-76-3 | 1g | $1647 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 56358 | 5-DehydroTolvaptan | 137973-76-3 | 50mg | $2200 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC151485 | N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide | 137973-76-3 | 2mg | $59 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC151485 | N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide | 137973-76-3 | 50mg | $704 | 2021-12-16 | Buy |
5-Dehydro Tolvaptan Chemical Properties,Uses,Production
Uses
5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g
Preparation
To a 3 L reactor was added 1- (4-amino-2-methylbenzoyl) -7-chloro-5-oxo-2,3,4,5-tetrahydro- 1 H- 1 -benzazepine (70. 0 g, 212.90 mmol), dichloromethane (560 ml) and distilled water (140 ml), and the mixture was stirred for 1 hour. Magnesium hydroxide (14.90 g, 14.90 mmol) was added to the reaction mixture at 10 ° C. or lower, and the mixture was stirred for 30 minutes. 2-Methylbenzoyl chloride (30.42 ml) was gradually added to the reaction mixture, stirring for 3 hours. The reaction mixture was filtered to remove magnesium hydroxide, and the pH of the reaction mixture was adjusted to pH 8 to 9 using an aqueous sodium hydroxide solution, and then the organic layer was separated. The obtained organic layer was dried with sodium sulfate (Na 2 SO 4), filtered, and concentrated under reduced pressure to give 5-Dehydro Tolvaptan (yield: 96 percent).
5-Dehydro Tolvaptan Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Enki Biopharmaceuticals (Shanghai) Limited | +86-0086-2157680326 +8613916707528 | yusu@enkibiopharma.com | China | 46 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18629 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 906 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from 5-Dehydro Tolvaptan manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-28 | Tolvaptan Impurity 4
137973-76-3
|
US $0.00-0.00 / mg | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
2019-08-05 | Tolvaptan Intermediate
137973-76-3
|
US $1.00 / g | 1g | 99% | 5 tons | Cangzhou Wanyou New Material Technology Co.,Ltd | ||
2019-07-06 | N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
137973-76-3
|
US $2.00 / kg | 1kg | 99% | Ask | Career Henan Chemical Co |
- Tolvaptan Impurity 4
137973-76-3
- US $0.00-0.00 / mg
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
- Tolvaptan Intermediate
137973-76-3
- US $1.00 / g
- 99%
- Cangzhou Wanyou New Material Technology Co.,Ltd
- N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
137973-76-3
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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