NVP-BHG712
- CAS No.
- 940310-85-0
- Chemical Name:
- NVP-BHG712
- Synonyms
- CS-688;CS-475;NSC5175;NSC 5175;NSC-5175;NVP-BHG712;NVP-BHG712 (BHG712);NVP-BHG712 USP/EP/BP;NVP-BHG 712; NVP BHG 712;4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluorome
- CBNumber:
- CB72522978
- Molecular Formula:
- C26H20F3N7O
- Molecular Weight:
- 503.48
- MDL Number:
- MFCD20272929
- MOL File:
- 940310-85-0.mol
- MSDS File:
- SDS
| Density | 1.41 |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | 13.20±0.70(Predicted) |
| color | white to beige |
| FDA UNII | N86NEM4R7Q |
NVP-BHG712 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0333 | NVP-BHG 712 ≥98% (HPLC) | 940310-85-0 | 5mg | $158 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0333 | NVP-BHG 712 ≥98% (HPLC) | 940310-85-0 | 25mg | $661 | 2024-03-01 | Buy |
| TCI Chemical | N1099 | NVP-BHG 712 >95.0%(HPLC) | 940310-85-0 | 50mg | $455 | 2024-03-01 | Buy |
| TCI Chemical | N1099 | NVP-BHG 712 >95.0%(HPLC) | 940310-85-0 | 10mg | $146 | 2022-04-27 | Buy |
| Cayman Chemical | 18489 | NVP-BHG 712 ≥98% | 940310-85-0 | 1mg | $37 | 2024-03-01 | Buy |
NVP-BHG712 Chemical Properties,Uses,Production
Uses
NVP-BHG712 can be used in biological study and therapeutic use of combinations of kinase inhibitors for treating colorectal cancer.
Uses
NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respectively.
Definition
ChEBI: 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide is a member of benzamides.
Biochem/physiol Actions
NVP-BHG712 is a very potent, selective inhbitor of the receptor tyrosine kinase EphB4 (ED50 = 25 nM). NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.
References
[1]. martiny-baron, g., et al., the small molecule specific ephb4 kinase inhibitor nvp-bhg712 inhibits vegf driven angiogenesis. angiogenesis, 2010. 13(3): p. 259-67.
[2]. kathawala, r.j., et al., the small molecule tyrosine kinase inhibitor nvp-bhg712 antagonizes abcc10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. oncotarget, 2015. 6(1): p. 510-21.
[3]. becerikli, m., et al., ephb4 tyrosine-kinase receptor expression and biological significance in soft tissue sarcoma. int j cancer, 2015. 136(8): p. 1781-91.
NVP-BHG712 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |