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N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

Biological activity In vitro In vivo Features
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea structure
CAS No.
950769-58-1
Chemical Name:
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
Synonyms
CS-53;Quizartinib;AC220, AC010220;Quizartinib, >98%;Quizartinib AC-220;AC220 (Quizartinib);AC-220; AC220;QUIZARTINIB;QUIZARTINIB (AC220), >98%;quizartinib (FLT3 inhibitor);AC220 (Quizartinib, AC010220)
CBNumber:
CB52514647
Molecular Formula:
C29H32N6O4S
Formula Weight:
560.66718
MOL File:
950769-58-1.mol

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Properties

Density 
1.39±0.1 g/cm3(Predicted)
form 
White powder.
pka
12.59±0.70(Predicted)
FDA UNII
7LA4O6Q0D3

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17986 Quizartinib ≥98% 950769-58-1 500μg $39 2020-06-24 Buy
Cayman Chemical 17986 Quizartinib ≥98% 950769-58-1 1mg $70 2020-06-24 Buy
Cayman Chemical 17986 Quizartinib ≥98% 950769-58-1 5mg $137 2020-06-24 Buy
Cayman Chemical 17986 Quizartinib ≥98% 950769-58-1 10mg $234 2020-06-24 Buy

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Chemical Properties,Uses,Production

Biological activity

Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 3.

In vitro

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity high selectivity, but high selectivity when inhibiting most protein kinase of the human. AC220 is a new selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

In vivo

In a xenograft tumor model, AC220 has nice drug attributes, good efficacy and high tolerability.. AC220 inhibits the activity of FLT3 and significantly extends survival in a mouse model of FLT3-ITD AML. Treatment with AC220 results in eradicating tumors in a xenograft tumor mouse model depended on FLT3. AC220 effectively inhibits the activity of FLT3 in primary cells of patients.

Features

Quizartinib (AC220) is a 2nd-generation FLT3 inhibitor as the first clinical drug candidate.

Definition

ChEBI: A member of the class of ureas that is urea in which one of the amino groups has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group while the other has been substituted by a phenyl group substituted at the para- position by n imidazo[2,1-b][1,3]benzothiazol-2-yl group that in turn is substituted at position 7 by a 2-(morpholin-4-yl)ethoxy group.

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Preparation Products And Raw materials

Raw materials

Preparation Products


N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Suppliers

Global( 137)Suppliers
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Capot Chemical Co.,Ltd.
+86-571-85586718
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View Lastest Price from N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-04 N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
950769-58-1
US $8.80 / KG 1KG 97%-99% 100kg career henan chemical co

950769-58-1(N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea)Related Search:


  • CS-53
  • AC-220; AC220;QUIZARTINIB
  • N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea AC-220
  • quizartinib (FLT3 inhibitor)
  • QUIZARTINIB (AC220), >98%
  • Quizartinib, >98%
  • 1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-y
  • N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
  • Quizartinib
  • Quizartinib AC-220
  • 2-(4-AMinophenyl)-7-(2-Morpholin-4-yl-ethoxy)iMidazo[2,1-b]-[1,3]benzothiazole
  • N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-Morpholin-4-ylethoxy)iMidazo[2,1-b][1,3]benzothiazol-2-yl]
  • AC220 (Quizartinib)
  • AC220 (Quizartinib, AC010220)
  • Urea,N-[5-(1,1-diMethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-Morpholinyl)ethoxy]iMidazo[2,1-b]benzothiazol-2-yl]phenyl]-
  • AC220, AC010220
  • 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2- Morpholinoethoxy)benzo[d]iMidazo[2,1-b]thiazol-2-yl)phenyl)urea
  • Quizartinib, 98%, a uniquely potent and selective Flt3 inhibitor
  • 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
  • N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea
  • 950769-58-1
  • C29H32N6O4S
  • Inhibitors
  • Anti-cancer
  • Inhibitor
  • Antineoplastic
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