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ChemicalBook >> CAS DataBase List >> NVP-BHG712

NVP-BHG712

NVP-BHG712 price.
  • $22 - $3950
  • Product name: NVP-BHG712
  • CAS: 940310-85-0
  • MF: C26H20F3N7O
  • MW: 503.48
  • EINECS:
  • MDL Number:MFCD20272929
  • Synonyms:NVP-BHG712;4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide;4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide;NVP-BHG712 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide;4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluorome;NVP-BHG 712; NVP BHG 712;CS-475;CS-688
Price66 Properties Safety Information Description
66 prices
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  • aablocks
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Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO(Solution)
  • 1mg
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  • 5mg
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  • 25mg
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  • 50.00mg
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  • 1G
  • 10mM(in1mLDMSO)
  • 1000mg
  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging1mg
  • Price$22
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide ≥98%
  • Packaging5mg
  • Price$38
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging10mg
  • Price$66
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging25mg
  • Price$111
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging50mg
  • Price$167
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging25MG
  • Price$265
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging100MG
  • Price$740
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging1G
  • Price$3950
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberX7502
  • Product descriptionNVP-BHG 712
  • Packaging5mg
  • Price$174
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging50mg
  • Price$192
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging100mg
  • Price$282
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging25mg
  • Price$127
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging1mg
  • Price$23
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging250mg
  • Price$470
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 1mg $22 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide ≥98% 5mg $38 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 10mg $66 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 25mg $111 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 50mg $167 2026-05-28 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 25MG $265 2026-05-27 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 100MG $740 2026-05-27 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 1G $3950 2026-05-27 Buy
AK Scientific X7502 NVP-BHG 712 5mg $174 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 50mg $192 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 100mg $282 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 25mg $127 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 5mg $50 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 10mg $75 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 1mg $23 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 250mg $470 2021-12-16 Buy
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Properties

Density :1.41
storage temp. :-20°C
solubility :DMSO: >15mg/mL
form :powder
pka :13.20±0.70(Predicted)
color :white to beige
InChIKey :ZCCPLJOKGAACRT-UHFFFAOYSA-N
SMILES :Cc1ccc(cc1Nc2nc(nc3n(C)ncc23)-c4cccnc4)C(=O)Nc5cccc(c5)C(F)(F)F

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

The EphB4 receptor tyrosine kinase (cloned from erythropoietin-producing hepatocellular carcinoma) and its ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. Signaling from this pair is also involved in tumor angiogenesis. NVP-BHG712 is an orally bioavailable inhibitor of EphB4 kinase autophosphorylation (ED50 = 25 nM). It is selective for EphB4, demonstrating an ED50 value of 4.2 μM at the related VEGFR2 receptor and ED50 values >10 μM against a panel of 40 additional kinases. At 3-30 mg/kg, NVP-BHG712 dose dependently inhibits VEGF-directed vessel formation in an in vivo mouse model of angiogenesis.

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Suppliers and manufacturers

Shanghai jerryxing Biomedical Technology Co., Ltd Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Jinan Trio PharmaTech Co., Ltd. BOC Sciences Dalian Meilun Biotech Co., Ltd. Shanghai civi chemical technology co.,Ltd NCE Biomedical Co.,Ltd. Haoyuan Chemexpress Co., Ltd. TOKYO CHEMICAL INDUSTRY CO., LTD.