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ChemicalBook >> CAS DataBase List >> NVP-BHG712

NVP-BHG712

NVP-BHG712 price.
  • $22 - $3950
  • Product name: NVP-BHG712
  • CAS: 940310-85-0
  • MF: C26H20F3N7O
  • MW: 503.48
  • EINECS:
  • MDL Number:MFCD20272929
  • Synonyms:NVP-BHG712;4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide;4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide;NVP-BHG712 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide;4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluorome;NVP-BHG 712; NVP BHG 712;CS-475;CS-688
Price78 Properties Safety Information Description
78 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
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  • DC Chemicals
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  • Usbiological
Package
  • 10mM*1mLinDMSO(Solution)
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 10mM(in1mLDMSO)
  • 25mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 50mg
  • 50.00mg
  • 100.00mg
  • 100MG
  • 200mg
  • 250mg
  • 1G
  • 1000mg
  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging1mg
  • Price$22
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide ≥98%
  • Packaging5mg
  • Price$38
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging10mg
  • Price$66
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging25mg
  • Price$111
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GU28
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99%
  • Packaging50mg
  • Price$167
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging25MG
  • Price$265
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging25MG
  • Price$265
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging100MG
  • Price$740
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging100MG
  • Price$740
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging1G
  • Price$3950
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT96305
  • Product descriptionNVP-BHG712 98%
  • Packaging1G
  • Price$3950
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberX7502
  • Product descriptionNVP-BHG 712
  • Packaging5mg
  • Price$174
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging100mg
  • Price$282
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging25mg
  • Price$127
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 1mg $22 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide ≥98% 5mg $38 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 10mg $66 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 25mg $111 2026-05-28 Buy
aablocks AA00GU28 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 99% 50mg $167 2026-05-28 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 25MG $265 2026-05-25 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 25MG $265 2026-05-27 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 100MG $740 2026-05-25 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 100MG $740 2026-05-27 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 1G $3950 2026-05-25 Buy
ACHEMBLOCK T96305 NVP-BHG712 98% 1G $3950 2026-05-27 Buy
AK Scientific X7502 NVP-BHG 712 5mg $174 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 100mg $282 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 25mg $127 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 5mg $50 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 10mg $75 2021-12-16 Buy
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Properties

Density :1.41
storage temp. :-20°C
solubility :DMSO: >15mg/mL
form :powder
pka :13.20±0.70(Predicted)
color :white to beige
InChIKey :ZCCPLJOKGAACRT-UHFFFAOYSA-N
SMILES :Cc1ccc(cc1Nc2nc(nc3n(C)ncc23)-c4cccnc4)C(=O)Nc5cccc(c5)C(F)(F)F

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

The EphB4 receptor tyrosine kinase (cloned from erythropoietin-producing hepatocellular carcinoma) and its ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. Signaling from this pair is also involved in tumor angiogenesis. NVP-BHG712 is an orally bioavailable inhibitor of EphB4 kinase autophosphorylation (ED50 = 25 nM). It is selective for EphB4, demonstrating an ED50 value of 4.2 μM at the related VEGFR2 receptor and ED50 values >10 μM against a panel of 40 additional kinases. At 3-30 mg/kg, NVP-BHG712 dose dependently inhibits VEGF-directed vessel formation in an in vivo mouse model of angiogenesis.

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